C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tyrosine kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105397 TYK2 9606 - 19:10350529-10380676 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264818 TYK2-201 10350529-10378508 protein_coding
  ENST00000524462 TYK2-003 10350533-10380565 protein_coding
  ENST00000524470 TYK2-016 10350853-10351285 retained_intron
  ENST00000525220 TYK2-011 10362580-10365863 protein_coding
  ENST00000525621 TYK2-001 10350533-10380676 protein_coding
  ENST00000525824 TYK2-007 10368122-10368741 protein_coding
  ENST00000525976 TYK2-015 10350533-10352492 protein_coding
  ENST00000527481 TYK2-020 10350947-10354522 nonsense_mediated_decay
  ENST00000529317 TYK2-009 10368063-10368539 retained_intron
  ENST00000529370 TYK2-002 10357385-10380525 protein_coding
  ENST00000529412 TYK2-021 10353911-10357901 retained_intron
  ENST00000529422 TYK2-017 10350788-10353137 processed_transcript
  ENST00000529739 TYK2-018 10352434-10354078 protein_coding
  ENST00000530220 TYK2-014 10350533-10353256 retained_intron
  ENST00000530560 TYK2-019 10350748-10356613 protein_coding
  ENST00000530829 TYK2-008 10368329-10380510 protein_coding
  ENST00000531620 TYK2-010 10361305-10362183 retained_intron
  ENST00000531836 TYK2-006 10368164-10380572 protein_coding
  ENST00000533334 TYK2-012 10357794-10361905 nonsense_mediated_decay
  ENST00000534228 TYK2-013 10354538-10357084 retained_intron
  ENST00000592137 TYK2-022 10351421-10354103 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264818ENST00000524462ENST00000525220ENST00000525621ENST00000525976ENST00000527481ENST00000529317ENST00000529370ENST00000529412ENST00000529739ENST00000530560ENST00000531620ENST00000531836
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264818 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.162±0.00 3.683±0.55 N/A
ENST00000524462 4.505±0.00 8.445±0.00 N/A 1.718±0.00 6.517±0.00 5.419±0.00 N/A 7.700±0.00 3.801±0.00 N/A 3.884±0.00 7.169±4.36 5.661±1.08 2.017±0.00
ENST00000525220 N/A N/A N/A 1.671±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000525621 7.457±0.00 8.881±0.00 N/A 1.660±0.00 N/A 3.297±0.00 2.917±2.29 3.106±2.29 2.766±2.41 8.036±0.00 10.009±0.00 5.145±2.55 5.031±0.36 3.041±1.75
ENST00000525976 N/A N/A N/A 6.842±0.00 N/A 13.923±0.00 N/A 12.616±8.66 N/A N/A 9.168±0.00 N/A N/A 7.672±0.00
ENST00000527481 N/A N/A N/A N/A N/A N/A N/A N/A 2.185±0.00 N/A N/A N/A N/A N/A
ENST00000529317 N/A N/A N/A N/A N/A N/A 2.379±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000529370 N/A N/A N/A 1.330±0.00 N/A N/A N/A N/A 0.374±0.00 0.556±0.00 1.730±0.00 N/A N/A N/A
ENST00000529412 N/A N/A N/A N/A N/A N/A N/A 2.400±0.00 N/A N/A N/A N/A N/A N/A
ENST00000529739 N/A 36.577±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000530560 N/A N/A N/A N/A N/A 4.848±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000531620 N/A N/A 4.051±0.00 N/A N/A N/A N/A 2.849±0.00 N/A N/A N/A N/A N/A N/A
ENST00000531836 N/A N/A N/A N/A N/A N/A N/A 2.650±0.00 2.363±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004GI CIL_0004GI_0001 CGP 19:10350529-10420121

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004713 TAS:IEA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005131 IPI growth hormone receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0006468 IEA:TAS protein phosphorylation
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0031702 IEA type 1 angiotensin receptor binding
GO:0035556 IEA intracellular signal transduction
GO:0060337 TAS type I interferon signaling pathway
GO:0060338 TAS regulation of type I interferon-mediated signaling pathway
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020326 tyk2 tyrosine kinase 2 protein_coding Danio_rerio
ENSMUSG00000032175 Tyk2 tyrosine kinase 2 protein_coding Mus_musculus

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