C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: multiple EGF-like-domains 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105429 MEGF8 9606 + 19:42325609-42378769 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000251268 MEGF8-002 42326244-42377786 protein_coding
  ENST00000334370 MEGF8-001 42325609-42378769 protein_coding
  ENST00000378073 MEGF8-201 42325609-42378769 protein_coding
  ENST00000593647 MEGF8-006 42369631-42377802 protein_coding
  ENST00000593840 MEGF8-003 42352796-42353668 retained_intron
  ENST00000598762 MEGF8-004 42360970-42378763 protein_coding
  ENST00000599787 MEGF8-005 42370628-42375962 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000251268ENST00000334370ENST00000378073ENST00000593647
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000251268 N/A N/A N/A N/A 0.223±0.00 N/A 0.692±0.00 N/A 0.495±0.00 N/A N/A N/A
ENST00000334370 2.821±0.00 N/A 4.344±0.00 2.821±0.00 1.062±0.92 0.082±0.00 1.519±0.00 N/A N/A 2.452±1.54 1.386±0.00 1.783±0.41
ENST00000378073 N/A 2.624±0.00 2.411±0.00 1.735±0.00 0.140±0.00 5.585±0.00 N/A 0.432±0.15 0.376±0.01 4.073±0.00 N/A 0.840±0.00
ENST00000593647 N/A N/A N/A N/A 0.707±0.00 0.259±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005V6 CIL_0005V6_0001 CGP 19:42313325-42378769
CIL_00053T CIL_00053T_0001 CGP 19:42325609-42390287

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003143 ISS embryonic heart tube morphogenesis
GO:0004872 IEA receptor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005634 ISS nucleus
GO:0007275 IEA multicellular organismal development
GO:0010468 ISS regulation of gene expression
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0030326 ISS embryonic limb morphogenesis
GO:0030509 ISS BMP signaling pathway
GO:0035108 IMP limb morphogenesis
GO:0042074 IMP cell migration involved in gastrulation
GO:0048704 ISS embryonic skeletal system morphogenesis
GO:0048842 ISS positive regulation of axon extension involved in axon guidance
GO:0055113 IMP epiboly involved in gastrulation with mouth forming second
GO:0060971 ISS embryonic heart tube left/right pattern formation
GO:0060972 IMP left/right pattern formation
GO:0061371 IMP determination of heart left/right asymmetry
GO:0070062 IDA extracellular vesicular exosome
GO:0071907 ISS determination of digestive tract left/right asymmetry
GO:0097094 IMP craniofacial suture morphogenesis
GO:0097155 ISS fasciculation of sensory neuron axon

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079751 megf8 multiple EGF-like-domains 8 protein_coding Danio_rerio
ENSMUSG00000045039 Megf8 multiple EGF-like-domains 8 protein_coding Mus_musculus

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