C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: deoxyribonuclease II, lysosomal
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105612 DNASE2 9606 - 19:12875211-12881468 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000222219 DNASE2-001 12875211-12881468 protein_coding
  ENST00000586547 DNASE2-003 12878038-12878834 retained_intron
  ENST00000588777 DNASE2-004 12875936-12878680 retained_intron
  ENST00000592506 DNASE2-002 12876254-12881466 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000222219ENST00000586547ENST00000588777ENST00000592506
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000222219 14.877±0.00 19.282±0.00 0.788±0.00 5.339±4.86 10.836±9.08 7.446±6.73 3.516±3.35 7.239±6.29 9.848±8.83 8.023±6.69 7.171±0.00 13.550±7.62 21.192±7.05 6.069±5.34
ENST00000586547 N/A N/A N/A N/A N/A N/A 0.143±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000588777 N/A N/A 0.481±0.00 N/A 1.212±0.00 2.452±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000592506 N/A N/A N/A N/A N/A N/A 0.101±0.00 N/A N/A N/A 1.135±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007VV CIL_0007VV_0001 VISTA 19:12752697-13356541
CIL_0007ZV CIL_0007ZV_0001 VISTA 19:12767682-13372012

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000737 IEA DNA catabolic process, endonucleolytic
GO:0003677 TAS DNA binding
GO:0004520 IEA endodeoxyribonuclease activity
GO:0004531 IBA:IEA deoxyribonuclease II activity
GO:0005622 IBA intracellular
GO:0005764 IEA lysosome
GO:0006259 TAS:IEA DNA metabolic process
GO:0006308 IEA DNA catabolic process
GO:0006309 IBA apoptotic DNA fragmentation
GO:0030218 IEA erythrocyte differentiation
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000073893 dnase2 deoxyribonuclease II, lysosomal protein_coding Danio_rerio
ENSMUSG00000003812 Dnase2a deoxyribonuclease II alpha protein_coding Mus_musculus

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