C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glycogen synthase kinase 3 alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105723 GSK3A 9606 - 19:42230186-42242625 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000222330 GSK3A-001 42230186-42242593 protein_coding
  ENST00000398249 GSK3A-002 42230190-42241893 protein_coding
  ENST00000453535 GSK3A-003 42230222-42242625 nonsense_mediated_decay
  ENST00000493059 GSK3A-004 42230542-42232837 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000222330ENST00000398249ENST00000453535ENST00000493059
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000222330 10.365±0.00 12.020±0.00 1.505±0.00 23.960±17.76 11.947±0.00 10.956±8.28 4.335±3.28 6.753±5.38 4.730±3.21 9.587±9.18 10.982±9.94 16.996±6.99 24.114±5.59 18.333±11.21
ENST00000398249 N/A N/A N/A N/A 0.368±0.00 0.600±0.00 0.238±0.00 0.314±0.00 N/A N/A N/A 0.361±0.00 N/A N/A
ENST00000453535 7.884±0.00 9.156±0.00 N/A 18.156±0.00 6.201±4.65 10.400±0.00 15.088±0.00 23.879±0.00 9.220±0.00 12.586±11.35 16.927±15.63 9.117±7.78 15.933±2.18 13.655±3.20
ENST00000493059 N/A N/A 2.363±0.00 N/A N/A N/A 1.175±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003UO CIL_0003UO_0002 CGP 19:42220271-42242625

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003073 ISS regulation of systemic arterial blood pressure
GO:0003214 ISS cardiac left ventricle morphogenesis
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005977 IEA glycogen metabolic process
GO:0006349 IEA regulation of gene expression by genetic imprinting
GO:0006468 IDA:IEA protein phosphorylation
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007399 IEA nervous system development
GO:0008286 ISS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010800 IEA positive regulation of peptidyl-threonine phosphorylation
GO:0010905 IC negative regulation of UDP-glucose catabolic process
GO:0016055 IEA Wnt signaling pathway
GO:0016477 IEA cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030819 ISS positive regulation of cAMP biosynthetic process
GO:0030877 TAS beta-catenin destruction complex
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0032007 ISS negative regulation of TOR signaling
GO:0032869 IMP cellular response to insulin stimulus
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0034236 IPI protein kinase A catalytic subunit binding
GO:0036016 ISS cellular response to interleukin-3
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0043161 ISS proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044027 IEA hypermethylation of CpG island
GO:0044267 TAS cellular protein metabolic process
GO:0045087 TAS innate immune response
GO:0045719 TAS negative regulation of glycogen biosynthetic process
GO:0045732 NAS positive regulation of protein catabolic process
GO:0045823 ISS positive regulation of heart contraction
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046325 IMP negative regulation of glucose import
GO:0046627 IMP negative regulation of insulin receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0050321 TAS tau-protein kinase activity
GO:0051348 IMP negative regulation of transferase activity
GO:0061052 ISS negative regulation of cell growth involved in cardiac muscle cell development
GO:0071285 IEA cellular response to lithium ion
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071879 ISS positive regulation of adrenergic receptor signaling pathway
GO:0090090 TAS negative regulation of canonical Wnt signaling pathway
GO:0097192 ISS extrinsic apoptotic signaling pathway in absence of ligand
GO:1901030 ISS positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000077 TAS negative regulation of type B pancreatic cell development
GO:2000466 TAS negative regulation of glycogen (starch) synthase activity
GO:2000467 ISS positive regulation of glycogen (starch) synthase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015681 gsk3ab glycogen synthase kinase 3 alpha b protein_coding Danio_rerio
ENSDARG00000029501 gsk3aa glycogen synthase kinase 3 alpha a protein_coding Danio_rerio
ENSMUSG00000057177 Gsk3a glycogen synthase kinase 3 alpha protein_coding Mus_musculus

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