C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glycogen synthase kinase 3 alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000057177 Gsk3a 10090 - 7:25228258-25237851 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000071739 Gsk3a-001 25228258-25237851 protein_coding
  ENSMUST00000108411 Gsk3a-002 25228258-25237851 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000071739ENSMUST00000108411
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000071739 20.522±3.35 24.335±4.30 26.705±1.69 52.086±14.54 22.697±4.50 29.326±4.39 18.318±0.73 22.835±1.18 20.604±7.29 18.208±2.69 32.154±1.63 28.926±6.09 24.873±9.26 20.913±0.64
ENSMUST00000108411 4.422±0.81 N/A N/A N/A N/A 4.780±0.00 N/A N/A N/A N/A N/A 5.339±0.00 6.407±0.00 3.042±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003UO CIL_0003UO_0003 CGP 7:25221451-25237851

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003073 IMP regulation of systemic arterial blood pressure
GO:0003214 IMP cardiac left ventricle morphogenesis
GO:0004672 IDA protein kinase activity
GO:0004674 IMP protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005977 IEA glycogen metabolic process
GO:0006349 IMP regulation of gene expression by genetic imprinting
GO:0006468 IDA protein phosphorylation
GO:0007399 IEA nervous system development
GO:0008286 IDA insulin receptor signaling pathway
GO:0010800 IDA positive regulation of peptidyl-threonine phosphorylation
GO:0016055 IEA Wnt signaling pathway
GO:0016477 IGI cell migration
GO:0030819 IMP positive regulation of cAMP biosynthetic process
GO:0032007 IMP negative regulation of TOR signaling
GO:0032869 IEA cellular response to insulin stimulus
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0034236 IEA protein kinase A catalytic subunit binding
GO:0036016 IDA cellular response to interleukin-3
GO:0043161 IDA proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044027 IMP hypermethylation of CpG island
GO:0045823 IMP positive regulation of heart contraction
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046325 IEA negative regulation of glucose import
GO:0046627 IEA negative regulation of insulin receptor signaling pathway
GO:0050321 IEA tau-protein kinase activity
GO:0051348 IEA negative regulation of transferase activity
GO:0061052 IMP negative regulation of cell growth involved in cardiac muscle cell development
GO:0071285 IDA cellular response to lithium ion
GO:0071407 IDA cellular response to organic cyclic compound
GO:0071879 IMP positive regulation of adrenergic receptor signaling pathway
GO:0097192 IDA extrinsic apoptotic signaling pathway in absence of ligand
GO:1901030 IDA positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000467 IMP positive regulation of glycogen (starch) synthase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015681 gsk3ab glycogen synthase kinase 3 alpha b protein_coding Danio_rerio
ENSDARG00000029501 gsk3aa glycogen synthase kinase 3 alpha a protein_coding Danio_rerio
ENSG00000105723 GSK3A glycogen synthase kinase 3 alpha protein_coding Homo_sapiens

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