C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: wingless-type MMTV integration site family member 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000105989 WNT2 9606 - 7:117276631-117323289 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265441 WNT2-002 117276631-117323289 protein_coding
  ENST00000449446 WNT2-001 117277531-117323114 nonsense_mediated_decay
  ENST00000461427 WNT2-003 117320469-117323152 retained_intron
  ENST00000491214 WNT2-004 117297726-117323041 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265441ENST00000449446ENST00000491214
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265441 N/A 0.306±0.00 0.135±0.06 0.533±0.05 0.019±0.00 0.045±0.00 0.140±0.00 0.281±0.02 2.505±1.51 N/A 0.601±0.20 17.956±8.77 N/A
ENST00000449446 0.091±0.00 0.482±0.00 0.128±0.02 0.514±0.00 N/A 0.035±0.00 0.211±0.06 0.581±0.36 7.422±0.00 0.495±0.00 0.876±0.20 39.322±16.43 0.677±0.39
ENST00000491214 0.050±0.00 N/A N/A N/A N/A 0.136±0.07 0.317±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003QW CIL_0003QW_0001 CGP 7:116953238-117323289
CIL_00063S CIL_00063S_0002 CGP 7:117276631-117428123

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0002053 IEA positive regulation of mesenchymal cell proliferation
GO:0002088 ISS lens development in camera-type eye
GO:0005102 IEA receptor binding
GO:0005109 IPI frizzled binding
GO:0005125 IDA cytokine activity
GO:0005515 IPI protein binding
GO:0005576 NAS:IEA extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IBA extracellular space
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0007267 IDA cell-cell signaling
GO:0007275 IEA multicellular organismal development
GO:0008284 IDA positive regulation of cell proliferation
GO:0016055 IDA:IEA Wnt signaling pathway
GO:0030182 ISS neuron differentiation
GO:0030324 IEA lung development
GO:0031012 IDA extracellular matrix
GO:0045165 IBA cell fate commitment
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048018 IC receptor agonist activity
GO:0048146 IMP positive regulation of fibroblast proliferation
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0055009 IEA atrial cardiac muscle tissue morphogenesis
GO:0060045 IEA positive regulation of cardiac muscle cell proliferation
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060317 IEA cardiac epithelial to mesenchymal transition
GO:0060492 IEA lung induction
GO:0060501 IEA positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060716 IEA labyrinthine layer blood vessel development
GO:0061072 ISS iris morphogenesis
GO:0061180 IEP mammary gland epithelium development
GO:0071300 ISS cellular response to retinoic acid
GO:0071560 IEP cellular response to transforming growth factor beta stimulus
GO:0090263 IMP positive regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041117 wnt2 wingless-type MMTV integration site family member 2 protein_coding Danio_rerio
ENSMUSG00000010797 Wnt2 wingless-type MMTV integration site family, member 2 protein_coding Mus_musculus

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