C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: LIM domain kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000106683 LIMK1 9606 + 7:74082933-74122525 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000336180 LIMK1-001 74083940-74122525 protein_coding
  ENST00000418310 LIMK1-002 74082933-74122525 protein_coding
  ENST00000435201 LIMK1-003 74083991-74121301 nonsense_mediated_decay
  ENST00000476792 LIMK1-008 74115368-74121029 retained_intron
  ENST00000483414 LIMK1-004 74097103-74111440 retained_intron
  ENST00000486361 LIMK1-006 74093956-74097189 processed_transcript
  ENST00000491052 LIMK1-007 74094233-74105905 processed_transcript
  ENST00000538333 LIMK1-005 74093079-74121458 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000336180ENST00000435201ENST00000476792ENST00000483414ENST00000491052ENST00000538333
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000336180 7.494±0.00 6.417±0.00 0.640±0.00 16.438±13.89 2.895±1.66 3.719±0.00 3.737±0.00 4.002±3.82 1.292±0.50 10.401±0.00 16.969±0.00 9.131±5.44 10.132±2.34 14.697±4.26
ENST00000435201 3.862±0.00 3.267±0.00 0.556±0.00 15.498±0.00 2.597±0.00 N/A N/A N/A N/A N/A 1.191±0.00 5.229±3.72 2.921±0.00 7.298±0.29
ENST00000476792 N/A N/A N/A N/A N/A N/A 0.291±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000483414 N/A N/A N/A N/A N/A 0.355±0.00 0.081±0.00 0.021±0.00 N/A N/A N/A N/A N/A N/A
ENST00000491052 N/A N/A N/A N/A N/A 0.801±0.00 N/A N/A N/A N/A 0.846±0.00 N/A N/A N/A
ENST00000538333 N/A N/A N/A N/A 2.157±0.00 1.275±0.00 N/A N/A N/A N/A N/A 4.889±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 NAS:IEA protein kinase activity
GO:0004674 TAS protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005925 IEA focal adhesion
GO:0006468 IDA:IEA protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007266 TAS Rho protein signal transduction
GO:0007399 TAS nervous system development
GO:0007411 TAS axon guidance
GO:0008270 IEA zinc ion binding
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0030036 TAS actin cytoskeleton organization
GO:0031072 IDA heat shock protein binding
GO:0032233 IDA positive regulation of actin filament bundle assembly
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043005 ISS neuron projection
GO:0045087 TAS innate immune response
GO:0045773 ISS positive regulation of axon extension
GO:0046982 IEA protein heterodimerization activity
GO:0051444 IDA negative regulation of ubiquitin-protein transferase activity
GO:0051496 IEA positive regulation of stress fiber assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003022 limk1b LIM domain kinase 1b protein_coding Danio_rerio
ENSDARG00000063651 limk1a LIM domain kinase 1a protein_coding Danio_rerio
ENSMUSG00000029674 Limk1 LIM-domain containing, protein kinase protein_coding Mus_musculus

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