C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transducin-like enhancer of split 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000106829 TLE4 9606 + 9:79571773-79726882 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265284 TLE4-018 79572745-79725233 protein_coding
  ENST00000376524 TLE4-019 79572634-79580118 processed_transcript
  ENST00000376525 TLE4-012 79572712-79575029 retained_intron
  ENST00000376537 TLE4-015 79572615-79725343 protein_coding
  ENST00000376544 TLE4-201 79571773-79726882 protein_coding
  ENST00000376552 TLE4-008 79571773-79725499 protein_coding
  ENST00000414465 TLE4-004 79572611-79652629 protein_coding
  ENST00000417836 TLE4-029 79706766-79709697 protein_coding
  ENST00000425506 TLE4-009 79573262-79652794 protein_coding
  ENST00000428713 TLE4-003 79573689-79708250 protein_coding
  ENST00000435650 TLE4-006 79572592-79704801 protein_coding
  ENST00000455913 TLE4-007 79573933-79652799 processed_transcript
  ENST00000461758 TLE4-013 79571941-79576802 nonsense_mediated_decay
  ENST00000462803 TLE4-016 79572625-79725340 nonsense_mediated_decay
  ENST00000463431 TLE4-026 79663450-79708162 processed_transcript
  ENST00000466428 TLE4-021 79573503-79627448 retained_intron
  ENST00000467142 TLE4-028 79704783-79709672 protein_coding
  ENST00000470872 TLE4-014 79572575-79725343 nonsense_mediated_decay
  ENST00000474519 TLE4-023 79575780-79652703 processed_transcript
  ENST00000476523 TLE4-020 79572638-79580185 processed_transcript
  ENST00000478290 TLE4-005 79708593-79722601 processed_transcript
  ENST00000483597 TLE4-024 79580227-79649724 processed_transcript
  ENST00000485159 TLE4-010 79573297-79627752 retained_intron
  ENST00000490347 TLE4-025 79652593-79708783 protein_coding
  ENST00000493163 TLE4-001 79652686-79671557 processed_transcript
  ENST00000495170 TLE4-027 79704645-79708226 retained_intron
  ENST00000496114 TLE4-030 79704803-79718963 protein_coding
  ENST00000496853 TLE4-022 79575779-79652737 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265284ENST00000376537ENST00000376544ENST00000376552ENST00000461758ENST00000470872ENST00000490347ENST00000495170
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265284 N/A 0.649±0.00 N/A N/A N/A N/A 1.371±0.00 2.134±0.00 N/A 2.494±0.07 N/A 1.229±0.00 31.953±14.55
ENST00000376537 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 20.613±1.93
ENST00000376544 4.536±0.00 N/A 2.205±0.47 N/A 0.991±0.21 N/A 1.174±0.00 N/A 3.576±0.00 0.732±0.00 3.869±2.47 2.658±2.11 10.651±5.27
ENST00000376552 N/A N/A 3.407±0.37 1.081±0.00 1.154±0.21 0.830±0.44 0.438±0.00 N/A 3.479±1.39 1.877±0.00 1.682±0.07 2.001±0.59 N/A
ENST00000461758 N/A 1.107±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 2.645±0.00 N/A N/A
ENST00000470872 N/A N/A N/A N/A 1.750±0.00 N/A 1.332±0.00 N/A N/A N/A 4.952±0.00 N/A N/A
ENST00000490347 N/A N/A 8.666±0.00 N/A 4.113±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000495170 N/A 3.746±0.00 N/A N/A 7.064±0.00 N/A 2.076±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008O8 CIL_0008O8_0001 VISTA 9:79095331-79696632
CIL_0007KE CIL_0007KE_0002 UCNEbase 9:79125686-82895571
CIL_0009CX CIL_0009CX_0001 VISTA 9:79204182-79805940
CIL_0009CZ CIL_0009CZ_0001 VISTA 9:79309170-79911842
CIL_00087P CIL_00087P_0001 VISTA 9:79329886-79931843
CIL_0009BM CIL_0009BM_0001 VISTA 9:79351142-79952138
CIL_0007V5 CIL_0007V5_0001 VISTA 9:79359339-79961438
CIL_0008CI CIL_0008CI_0001 VISTA 9:79361205-79963619

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0003674 ND molecular_function
GO:0003682 IEA chromatin binding
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003714 IEA transcription corepressor activity
GO:0005515 IEA protein binding
GO:0005634 NAS nucleus
GO:0005654 TAS nucleoplasm
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007219 TAS Notch signaling pathway
GO:0008150 ND biological_process
GO:0016055 IEA Wnt signaling pathway
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0070491 IEA repressing transcription factor binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000024642 Tle4 transducin-like enhancer of split 4, homolog of Drosophila E(spl) protein_coding Mus_musculus

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