C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000107643 MAPK8 9606 + 10:48306639-48439360 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000360332 MAPK8-201 48401612-48439357 protein_coding
  ENST00000374174 MAPK8-013 48401661-48425831 protein_coding
  ENST00000374176 MAPK8-014 48401648-48439360 protein_coding
  ENST00000374179 MAPK8-012 48401644-48439360 protein_coding
  ENST00000374182 MAPK8-011 48401643-48439360 protein_coding
  ENST00000374189 MAPK8-006 48306690-48439360 protein_coding
  ENST00000395611 MAPK8-202 48306639-48439357 protein_coding
  ENST00000426557 MAPK8-009 48307026-48410144 protein_coding
  ENST00000429041 MAPK8-004 48306680-48420246 protein_coding
  ENST00000432379 MAPK8-008 48306655-48410146 protein_coding
  ENST00000459755 MAPK8-002 48429893-48435877 processed_transcript
  ENST00000469110 MAPK8-001 48425189-48436440 retained_intron
  ENST00000469879 MAPK8-005 48424519-48434898 processed_transcript
  ENST00000471272 MAPK8-003 48424569-48427410 retained_intron
  ENST00000476134 MAPK8-010 48308216-48410328 processed_transcript
  ENST00000482840 MAPK8-007 48425854-48426612 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000360332ENST00000374174ENST00000374176ENST00000374179ENST00000374182ENST00000374189ENST00000395611ENST00000459755ENST00000469110ENST00000469879
Transcript ID Adipose Adrenal Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000360332 0.949±0.00 N/A N/A N/A N/A 1.324±0.00 N/A N/A N/A 0.696±0.00 0.590±0.00 N/A
ENST00000374174 N/A N/A N/A N/A 3.162±0.00 N/A 7.658±0.00 8.490±0.00 2.042±0.00 9.966±5.04 N/A 9.305±0.00
ENST00000374176 N/A N/A N/A N/A N/A 1.308±0.26 N/A 1.145±0.00 0.347±0.11 1.463±0.00 0.752±0.00 N/A
ENST00000374179 1.508±0.00 N/A N/A 1.103±0.00 0.278±0.00 N/A 1.422±0.00 0.768±0.00 0.287±0.00 1.616±1.10 0.971±0.00 1.555±0.40
ENST00000374182 N/A N/A 3.920±0.59 N/A N/A N/A N/A N/A 0.283±0.00 N/A N/A N/A
ENST00000374189 N/A 0.662±0.00 1.776±0.64 0.940±0.00 N/A N/A N/A N/A N/A 1.320±0.00 N/A 1.712±0.00
ENST00000395611 0.796±0.00 1.101±0.00 0.884±0.00 0.672±0.00 2.014±0.00 N/A N/A 0.512±0.00 N/A 1.272±0.00 0.943±0.18 1.429±0.00
ENST00000459755 N/A N/A N/A N/A N/A N/A N/A N/A 0.689±0.00 N/A N/A N/A
ENST00000469110 N/A 0.774±0.00 N/A 0.651±0.00 N/A N/A N/A 1.264±0.00 N/A 2.598±0.00 N/A N/A
ENST00000469879 N/A N/A N/A N/A N/A 7.926±0.00 4.003±0.00 6.188±0.00 3.062±0.00 10.333±0.14 6.264±1.61 15.365±0.61

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0001503 IEA ossification
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0003824 IEA catalytic activity
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004705 IDA JUN kinase activity
GO:0004707 IEA MAP kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006915 TAS apoptotic process
GO:0006950 TAS response to stress
GO:0007254 IDA JNK cascade
GO:0007258 IDA JUN phosphorylation
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0009411 IDA response to UV
GO:0010468 IEA regulation of gene expression
GO:0010628 IMP positive regulation of gene expression
GO:0016020 IEA membrane
GO:0016301 IEA kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IMP peptidyl-threonine phosphorylation
GO:0031063 IMP regulation of histone deacetylation
GO:0032091 IDA negative regulation of protein binding
GO:0032880 IDA regulation of protein localization
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035033 IMP histone deacetylase regulator activity
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042826 IPI histone deacetylase binding
GO:0043065 TAS positive regulation of apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0046686 IEA response to cadmium ion
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051090 TAS regulation of sequence-specific DNA binding transcription factor activity
GO:0051403 TAS stress-activated MAPK cascade
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0071260 IEP cellular response to mechanical stimulus
GO:0071732 IEA cellular response to nitric oxide
GO:0090045 IMP positive regulation of deacetylase activity
GO:0097190 TAS apoptotic signaling pathway
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:0097300 IEA programmed necrotic cell death
GO:1900740 TAS positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000017 IEA positive regulation of determination of dorsal identity
GO:2001235 IEA positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009870 mapk8b mitogen-activated protein kinase 8b protein_coding Danio_rerio
ENSDARG00000031888 mapk8a mitogen-activated protein kinase 8a protein_coding Danio_rerio
ENSMUSG00000021936 Mapk8 mitogen-activated protein kinase 8 protein_coding Mus_musculus

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