C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mitogen-activated protein kinase 8
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000374179 MAPK8-012 ENSG00000107643 9606 + 10:48401644-48439360 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBreastHeartLiverLungMuscleOvaryPlacentaTestisENST00000374179
Transcript ID Adipose Breast Heart Liver Lung Muscle Ovary Placenta Testis
ENST00000374179 1.508±0.00 1.103±0.00 0.278±0.00 1.422±0.00 0.768±0.00 0.287±0.00 1.616±1.10 0.971±0.00 1.555±0.40

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004705 IDA JUN kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006915 TAS apoptotic process
GO:0006950 TAS response to stress
GO:0007254 IDA JNK cascade
GO:0007258 IDA JUN phosphorylation
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0009411 IDA response to UV
GO:0010628 IMP positive regulation of gene expression
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018107 IMP peptidyl-threonine phosphorylation
GO:0031063 IMP regulation of histone deacetylation
GO:0032091 IDA negative regulation of protein binding
GO:0032880 IDA regulation of protein localization
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035033 IMP histone deacetylase regulator activity
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042826 IPI histone deacetylase binding
GO:0043065 TAS positive regulation of apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051090 TAS regulation of sequence-specific DNA binding transcription factor activity
GO:0051403 TAS stress-activated MAPK cascade
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0071260 IEP cellular response to mechanical stimulus
GO:0090045 IMP positive regulation of deacetylase activity
GO:0097190 TAS apoptotic signaling pathway
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:1900740 TAS positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000111945 Mapk8-001 protein_coding Mus_musculus 0 3380
ENSMUST00000022504 Mapk8-002 protein_coding Mus_musculus 0 3127
ENSMUST00000111943 Mapk8-004 protein_coding Mus_musculus 0 1995
ENSMUST00000111944 Mapk8-003 protein_coding Mus_musculus 0 1893
ENSMUST00000130539 Mapk8-006 retained_intron Mus_musculus 0 1000
ENSMUST00000111942 Mapk8-005 protein_coding Mus_musculus 0 976
ENSMUST00000150659 Mapk8-008 processed_transcript Mus_musculus 0 761
ENSDART00000049180 mapk8a-201 protein_coding Danio_rerio 0 743
ENSDART00000139591 mapk8a-001 protein_coding Danio_rerio 0 743
ENSDART00000022471 mapk8b-001 protein_coding Danio_rerio 0 725
ENSDART00000128677 mapk8b-002 protein_coding Danio_rerio 0 702
ENSMUST00000127143 Mapk8-009 retained_intron Mus_musculus 0 580
ENSMUST00000132379 Mapk8-007 retained_intron Mus_musculus 0 418

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