C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021936 Mapk8 10090 - 14:33377898-33447158 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000022504 Mapk8-002 33381049-33447145 protein_coding
  ENSMUST00000111942 Mapk8-005 33382308-33410977 protein_coding
  ENSMUST00000111943 Mapk8-004 33382170-33410994 protein_coding
  ENSMUST00000111944 Mapk8-003 33382105-33447142 protein_coding
  ENSMUST00000111945 Mapk8-001 33377898-33447158 protein_coding
  ENSMUST00000127143 Mapk8-009 33383923-33389228 retained_intron
  ENSMUST00000130539 Mapk8-006 33390938-33447158 retained_intron
  ENSMUST00000132379 Mapk8-007 33406871-33447157 retained_intron
  ENSMUST00000150659 Mapk8-008 33382305-33390308 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022504ENSMUST00000111942ENSMUST00000111943ENSMUST00000111944ENSMUST00000111945ENSMUST00000132379ENSMUST00000150659
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022504 4.398±2.08 3.905±1.11 2.562±0.36 10.906±3.02 4.275±0.49 4.349±1.13 4.008±0.51 2.922±0.19 3.956±0.68 3.677±0.68 2.385±0.23 5.195±2.33 4.619±1.08 4.110±0.88
ENSMUST00000111942 N/A N/A N/A 29.041±0.00 N/A N/A N/A N/A N/A N/A N/A 12.328±0.00 12.204±0.53 18.920±0.00
ENSMUST00000111943 N/A N/A N/A N/A N/A N/A N/A N/A 3.591±0.26 N/A 3.025±0.51 7.630±1.70 5.663±1.81 4.619±0.90
ENSMUST00000111944 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.947±0.30
ENSMUST00000111945 0.834±0.56 N/A 0.543±0.00 14.258±5.91 1.196±0.39 N/A N/A N/A 1.581±0.90 N/A 0.860±0.26 1.622±0.00 1.601±0.74 0.569±0.00
ENSMUST00000132379 N/A 9.640±1.25 N/A N/A 3.113±0.33 6.088±0.20 N/A N/A N/A N/A N/A 10.705±3.23 N/A N/A
ENSMUST00000150659 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 13.334±0.00 15.110±0.00 57.856±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006H2 CIL_0006H2_0003 CGP 14:33214026-33447158
CIL_0007BW CIL_0007BW_0003 CGP 14:33377898-33640754

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001503 IMP ossification
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004705 IDA JUN kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005829 IDA cytosol
GO:0006468 IDA protein phosphorylation
GO:0007254 ISO JNK cascade
GO:0007258 IMP JUN phosphorylation
GO:0009411 IEA response to UV
GO:0010468 IMP regulation of gene expression
GO:0010628 IEA positive regulation of gene expression
GO:0016301 IDA kinase activity
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0018107 IMP peptidyl-threonine phosphorylation
GO:0031063 IEA regulation of histone deacetylation
GO:0032091 IEA negative regulation of protein binding
GO:0032880 IEA regulation of protein localization
GO:0035033 IEA histone deacetylase regulator activity
GO:0042826 IEA histone deacetylase binding
GO:0043066 IEA negative regulation of apoptotic process
GO:0046686 IGI response to cadmium ion
GO:0048263 ISO determination of dorsal identity
GO:0070301 IDA cellular response to hydrogen peroxide
GO:0071222 ISO cellular response to lipopolysaccharide
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071732 IMP cellular response to nitric oxide
GO:0090045 IEA positive regulation of deacetylase activity
GO:0097300 IMP programmed necrotic cell death
GO:2000017 IDA positive regulation of determination of dorsal identity
GO:2001235 IGI positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009870 mapk8b mitogen-activated protein kinase 8b protein_coding Danio_rerio
ENSDARG00000031888 mapk8a mitogen-activated protein kinase 8a protein_coding Danio_rerio
ENSG00000107643 MAPK8 mitogen-activated protein kinase 8 protein_coding Homo_sapiens

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