C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: karyopherin (importin) beta 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108424 KPNB1 9606 + 17:47649476-47685505 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000290158 KPNB1-001 47649838-47685505 protein_coding
  ENST00000535458 KPNB1-002 47649476-47682633 protein_coding
  ENST00000540627 KPNB1-003 47651196-47682680 protein_coding
  ENST00000577875 KPNB1-007 47650358-47658641 protein_coding
  ENST00000577918 KPNB1-006 47650152-47662238 processed_transcript
  ENST00000578718 KPNB1-009 47670377-47674755 processed_transcript
  ENST00000579901 KPNB1-014 47670324-47676486 processed_transcript
  ENST00000580019 KPNB1-010 47673089-47673839 retained_intron
  ENST00000580158 KPNB1-012 47679880-47682589 retained_intron
  ENST00000580573 KPNB1-011 47677048-47678639 retained_intron
  ENST00000582097 KPNB1-004 47656925-47682680 protein_coding
  ENST00000582126 KPNB1-013 47680603-47684511 nonsense_mediated_decay
  ENST00000583013 KPNB1-008 47668365-47673561 protein_coding
  ENST00000583648 KPNB1-005 47649495-47657023 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000290158ENST00000535458ENST00000540627ENST00000577875ENST00000580158ENST00000582097
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000290158 18.625±0.00 8.007±0.00 2.810±0.00 16.343±12.10 5.377±1.82 20.212±14.69 6.953±4.15 14.522±12.06 8.057±0.63 12.998±7.38 24.092±23.29 29.226±5.79 16.060±4.82 28.521±19.46
ENST00000535458 12.659±0.00 17.432±0.00 3.278±0.00 5.762±0.00 11.588±3.49 6.433±0.00 14.008±0.00 9.174±0.00 13.733±0.00 11.585±0.00 4.807±0.00 24.699±0.50 18.150±0.00 44.842±10.89
ENST00000540627 N/A N/A N/A N/A N/A 6.654±0.00 8.524±0.00 3.751±0.00 N/A 5.990±0.00 N/A N/A 5.753±0.00 N/A
ENST00000577875 N/A N/A N/A N/A 17.931±0.00 N/A N/A N/A N/A N/A 14.385±0.00 N/A N/A N/A
ENST00000580158 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 262.158±0.00 150.143±0.00 382.526±0.00
ENST00000582097 11.214±0.00 N/A 4.244±0.00 5.800±0.00 4.741±0.00 N/A N/A N/A 7.197±0.00 7.938±0.00 2.745±0.00 11.466±1.61 9.648±0.51 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 TAS protein import into nucleus, translocation
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005635 IDA nuclear envelope
GO:0005643 TAS nuclear pore
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006309 TAS apoptotic DNA fragmentation
GO:0006606 IDA protein import into nucleus
GO:0006607 TAS NLS-bearing protein import into nucleus
GO:0006610 IDA ribosomal protein import into nucleus
GO:0006886 IEA intracellular protein transport
GO:0006915 TAS apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0008139 TAS nuclear localization sequence binding
GO:0008270 TAS zinc ion binding
GO:0008536 IEA Ran GTPase binding
GO:0008565 IEA protein transporter activity
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0019058 TAS viral life cycle
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0019899 IPI enzyme binding
GO:0019904 IPI protein domain specific binding
GO:0031965 IDA nuclear membrane
GO:0043234 IEA protein complex
GO:0044281 TAS small molecule metabolic process
GO:0044822 IDA poly(A) RNA binding
GO:0070062 IDA extracellular vesicular exosome
GO:0071782 IDA endoplasmic reticulum tubular network
GO:0075733 TAS intracellular transport of virus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008680 kpnb1 karyopherin (importin) beta 1 protein_coding Danio_rerio
ENSMUSG00000001440 Kpnb1 karyopherin (importin) beta 1 protein_coding Mus_musculus

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