C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: profilin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108518 PFN1 9606 - 17:4945652-4949061 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000225655 PFN1-001 4945652-4949014 protein_coding
  ENST00000572383 PFN1-003 4946693-4949061 protein_coding
  ENST00000574872 PFN1-002 4945667-4947469 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonLiverLungOvaryPlacentaTestisENST00000225655ENST00000572383ENST00000574872
Transcript ID Bladder Brain Breast Colon Liver Lung Ovary Placenta Testis
ENST00000225655 2.876±0.00 3.371±0.00 7.621±0.00 N/A 7.616±0.00 4.891±0.00 24.151±20.20 N/A N/A
ENST00000572383 N/A N/A N/A 38.127±0.00 15.638±0.00 9.387±0.00 287.557±30.84 267.494±0.00 91.877±0.00
ENST00000574872 N/A N/A 4.617±0.00 N/A N/A 6.169±0.00 2.394±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000C6 CIL_0000C6_0001 CGP 17:4940008-4949061
CIL_000060 CIL_000060_0001 CGP 17:4945652-4957131

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000774 IDA adenyl-nucleotide exchange factor activity
GO:0001843 IEA neural tube closure
GO:0002576 TAS platelet degranulation
GO:0003779 IPI actin binding
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005546 IDA phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005925 IDA focal adhesion
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0007596 TAS blood coagulation
GO:0008219 IEA cell death
GO:0010033 IEA response to organic substance
GO:0010634 IMP positive regulation of epithelial cell migration
GO:0016020 IDA membrane
GO:0017048 IEA Rho GTPase binding
GO:0030036 IEA actin cytoskeleton organization
GO:0030168 TAS platelet activation
GO:0030837 IDA negative regulation of actin filament polymerization
GO:0030838 IGI positive regulation of actin filament polymerization
GO:0032232 IMP negative regulation of actin filament bundle assembly
GO:0032781 IDA positive regulation of ATPase activity
GO:0043005 IEA neuron projection
GO:0044822 IDA poly(A) RNA binding
GO:0045202 IEA synapse
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0050434 IEA positive regulation of viral transcription
GO:0051054 IEA positive regulation of DNA metabolic process
GO:0051496 IEA positive regulation of stress fiber assembly
GO:0051497 IMP negative regulation of stress fiber assembly
GO:0070062 IDA extracellular vesicular exosome
GO:0070064 IPI proline-rich region binding
GO:0071363 IEA cellular response to growth factor stimulus
GO:0072562 IDA blood microparticle
GO:1900029 IMP positive regulation of ruffle assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000018293 Pfn1 profilin 1 protein_coding Mus_musculus

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