C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: profilin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000018293 Pfn1 10090 - 11:70651850-70654644 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000018437 Pfn1-001 70651850-70654644 protein_coding
  ENSMUST00000108549 Pfn1-002 70652622-70654598 protein_coding
  ENSMUST00000177669 Pfn1-003 70652612-70654608 retained_intron
  ENSMUST00000178254 Pfn1-004 70651939-70654621 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000018437ENSMUST00000108549ENSMUST00000177669ENSMUST00000178254
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000018437 423.009±78.06 843.288±258.90 698.872±8.08 135.595±70.52 864.353±423.56 1336.212±153.93 176.106±33.81 314.712±27.67 352.284±107.54 466.238±126.02 153.817±17.72 925.451±380.41 506.645±326.00 54.944±30.16
ENSMUST00000108549 N/A N/A N/A 39.331±0.00 N/A N/A N/A N/A N/A N/A N/A 170.279±0.00 249.586±161.68 19.811±0.00
ENSMUST00000177669 N/A N/A N/A 12.805±0.00 N/A N/A N/A N/A N/A N/A N/A 19.181±0.00 6.929±0.00 3.105±2.79
ENSMUST00000178254 121.511±24.43 813.832±371.87 N/A N/A 461.679±48.21 308.190±77.46 N/A N/A N/A N/A N/A 348.574±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000C6 CIL_0000C6_0002 CGP 11:70647235-70654644
CIL_000060 CIL_000060_0002 CGP 11:70651850-70662513

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000774 IEA adenyl-nucleotide exchange factor activity
GO:0001843 IGI neural tube closure
GO:0003779 IEA actin binding
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005546 IEA phosphatidylinositol-4,5-bisphosphate binding
GO:0005576 TAS extracellular region
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005925 IEA focal adhesion
GO:0006357 IGI regulation of transcription from RNA polymerase II promoter
GO:0008064 TAS regulation of actin polymerization or depolymerization
GO:0010033 IEA response to organic substance
GO:0010634 IEA positive regulation of epithelial cell migration
GO:0016020 IEA membrane
GO:0017048 IPI Rho GTPase binding
GO:0030036 IEA actin cytoskeleton organization
GO:0030837 IEA negative regulation of actin filament polymerization
GO:0030838 IEA positive regulation of actin filament polymerization
GO:0032232 IEA negative regulation of actin filament bundle assembly
GO:0032781 IEA positive regulation of ATPase activity
GO:0042989 TAS sequestering of actin monomers
GO:0043005 IEA neuron projection
GO:0044822 IEA poly(A) RNA binding
GO:0045202 IEA synapse
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0050434 IEA positive regulation of viral transcription
GO:0051054 IEA positive regulation of DNA metabolic process
GO:0051496 IEA positive regulation of stress fiber assembly
GO:0051497 IEA negative regulation of stress fiber assembly
GO:0070062 IEA extracellular vesicular exosome
GO:0070064 IEA proline-rich region binding
GO:0071363 IEA cellular response to growth factor stimulus
GO:0072562 IEA blood microparticle
GO:1900029 IEA positive regulation of ruffle assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000108518 PFN1 profilin 1 protein_coding Homo_sapiens

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