C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: arachidonate 12-lipoxygenase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108839 ALOX12 9606 + 17:6996065-7010736 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000251535 ALOX12-001 6996065-7010736 protein_coding
  ENST00000406228 ALOX12-002 7009489-7010736 retained_intron
  ENST00000480801 ALOX12-003 6996982-7000469 protein_coding

Expression Patterns

No expression data.

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004052 IDA arachidonate 12-lipoxygenase activity
GO:0005506 IEA iron ion binding
GO:0005515 IPI:IEA protein binding
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0006928 IMP cellular component movement
GO:0007568 IEA aging
GO:0008284 ISS positive regulation of cell proliferation
GO:0010595 IEA positive regulation of endothelial cell migration
GO:0010628 IEA positive regulation of gene expression
GO:0010656 IMP negative regulation of muscle cell apoptotic process
GO:0010942 IEA positive regulation of cell death
GO:0016020 IDA membrane
GO:0016165 IDA linoleate 13S-lipoxygenase activity
GO:0016702 TAS:IEA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019369 ISS arachidonic acid metabolic process
GO:0019372 IDA lipoxygenase pathway
GO:0019395 IMP fatty acid oxidation
GO:0030307 IMP positive regulation of cell growth
GO:0030335 IMP positive regulation of cell migration
GO:0042383 IDA sarcolemma
GO:0042554 NAS superoxide anion generation
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 ISS negative regulation of apoptotic process
GO:0043280 IEA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043651 IDA linoleic acid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045603 IEA positive regulation of endothelial cell differentiation
GO:0045766 IMP positive regulation of angiogenesis
GO:0045785 IMP positive regulation of cell adhesion
GO:0045909 IEA positive regulation of vasodilation
GO:0046872 IEA metal ion binding
GO:0047977 ISS hepoxilin-epoxide hydrolase activity
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0051120 TAS hepoxilin A3 synthase activity
GO:0051121 TAS hepoxilin metabolic process
GO:0051122 ISS hepoxilin biosynthetic process
GO:0051901 IEA positive regulation of mitochondrial depolarization
GO:0055114 IEA oxidation-reduction process
GO:0061436 ISS establishment of skin barrier
GO:0070062 IDA extracellular vesicular exosome
GO:0071396 IEA cellular response to lipid
GO:0072593 NAS reactive oxygen species metabolic process
GO:0090331 ISS negative regulation of platelet aggregation
GO:1901751 IDA leukotriene A4 metabolic process
GO:2001300 TAS lipoxin metabolic process
GO:2001303 IDA lipoxin A4 biosynthetic process
GO:2001306 IDA lipoxin B4 biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069463 alox12 arachidonate 12-lipoxygenase protein_coding Danio_rerio
ENSMUSG00000000320 Alox12 arachidonate 12-lipoxygenase protein_coding Mus_musculus

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