C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: arachidonate 12-lipoxygenase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000000320 Alox12 10090 - 11:70241457-70255353 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000000329 Alox12-001 70241457-70255353 protein_coding
  ENSMUST00000108574 Alox12-002 70248963-70255341 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000000329ENSMUST00000108574
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000000329 1.909±0.94 1.181±0.33 1.562±0.07 0.259±0.10 1.645±0.46 0.790±0.20 2.106±0.28 1.972±0.64 3.196±3.58 2.680±0.61 0.329±0.13 3.354±0.94 0.812±0.38 1.909±0.33
ENSMUST00000108574 0.778±0.07 N/A 1.160±0.11 0.071±0.02 0.370±0.04 0.194±0.02 N/A 0.510±0.03 0.049±0.00 N/A 0.309±0.11 0.745±0.13 0.406±0.32 0.571±0.08

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004052 ISS arachidonate 12-lipoxygenase activity
GO:0005506 IEA iron ion binding
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0006928 ISS cellular component movement
GO:0007568 IEA aging
GO:0008284 IMP positive regulation of cell proliferation
GO:0010595 IEA positive regulation of endothelial cell migration
GO:0010628 IEA positive regulation of gene expression
GO:0010656 ISS negative regulation of muscle cell apoptotic process
GO:0010942 IEA positive regulation of cell death
GO:0016020 ISS membrane
GO:0016165 IEA linoleate 13S-lipoxygenase activity
GO:0016702 IEA oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019369 IDA arachidonic acid metabolic process
GO:0019372 IDA lipoxygenase pathway
GO:0019395 ISS fatty acid oxidation
GO:0030307 ISS positive regulation of cell growth
GO:0030335 ISS positive regulation of cell migration
GO:0042383 ISS sarcolemma
GO:0043065 ISS positive regulation of apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043280 IEA positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043651 ISS linoleic acid metabolic process
GO:0045603 IEA positive regulation of endothelial cell differentiation
GO:0045766 ISS positive regulation of angiogenesis
GO:0045785 ISS positive regulation of cell adhesion
GO:0045909 IEA positive regulation of vasodilation
GO:0047977 ISS hepoxilin-epoxide hydrolase activity
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0051122 ISS hepoxilin biosynthetic process
GO:0051901 IEA positive regulation of mitochondrial depolarization
GO:0055114 IEA oxidation-reduction process
GO:0061436 IMP establishment of skin barrier
GO:0070062 IEA extracellular vesicular exosome
GO:0071396 IEA cellular response to lipid
GO:0090331 IMP negative regulation of platelet aggregation
GO:1901751 ISS leukotriene A4 metabolic process
GO:2001303 ISS lipoxin A4 biosynthetic process
GO:2001306 ISS lipoxin B4 biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069463 alox12 arachidonate 12-lipoxygenase protein_coding Danio_rerio
ENSG00000108839 ALOX12 arachidonate 12-lipoxygenase protein_coding Homo_sapiens

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