C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108984 MAP2K6 9606 + 17:69414698-69543331 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000359094 MAP2K6-005 69414834-69542510 nonsense_mediated_decay
  ENST00000586641 MAP2K6-003 69414711-69521833 retained_intron
  ENST00000588110 MAP2K6-008 69502266-69520278 protein_coding
  ENST00000589295 MAP2K6-006 69502154-69520324 protein_coding
  ENST00000589647 MAP2K6-004 69502429-69542019 protein_coding
  ENST00000590474 MAP2K6-001 69414698-69543331 protein_coding
  ENST00000591445 MAP2K6-002 69505448-69521826 retained_intron
  ENST00000592348 MAP2K6-007 69536066-69542011 retained_intron
  ENST00000613873 MAP2K6-201 69502429-69542017 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359094ENST00000586641ENST00000588110ENST00000589295ENST00000589647ENST00000590474ENST00000591445ENST00000592348ENST00000613873
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359094 N/A 0.641±0.00 N/A 0.371±0.00 0.304±0.00 0.416±0.00 0.189±0.00 3.476±0.00 0.044±0.00 0.224±0.11 N/A 0.847±0.00 0.360±0.16 0.219±0.00
ENST00000586641 N/A N/A N/A N/A N/A N/A 0.118±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000588110 N/A N/A N/A N/A 2.222±0.00 N/A N/A N/A 0.259±0.00 N/A N/A N/A N/A 0.789±0.00
ENST00000589295 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.246±0.00 N/A N/A
ENST00000589647 0.880±0.00 1.857±0.00 N/A N/A 0.602±0.00 N/A N/A 1.242±0.00 N/A 0.681±0.00 6.348±0.00 2.841±2.22 0.110±0.00 N/A
ENST00000590474 N/A N/A 1.410±0.00 0.699±0.18 0.317±0.06 2.012±0.00 N/A 0.310±0.00 0.632±0.00 0.240±0.00 N/A 0.564±0.22 0.179±0.10 N/A
ENST00000591445 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.314±0.00 N/A N/A
ENST00000592348 N/A N/A N/A N/A N/A 0.986±0.00 N/A N/A 0.199±0.00 N/A N/A N/A 0.703±0.00 0.937±0.00
ENST00000613873 N/A N/A N/A 0.542±0.00 N/A N/A 0.226±0.10 N/A 0.252±0.00 0.421±0.00 N/A N/A 0.581±0.48 0.875±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006H0 CIL_0006H0_0001 CGP 17:69244311-69543331
CIL_00072F CIL_00072F_0001 CGP 17:69414698-70135608

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000187 TAS activation of MAPK activity
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0002931 IEA response to ischemia
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IEA MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0006975 TAS DNA damage induced protein phosphorylation
GO:0007050 TAS cell cycle arrest
GO:0007165 TAS signal transduction
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0022602 IEA ovulation cycle process
GO:0032308 IEA positive regulation of prostaglandin secretion
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042493 IEA response to drug
GO:0042692 TAS muscle cell differentiation
GO:0043065 IEA positive regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0051149 TAS positive regulation of muscle cell differentiation
GO:0051403 TAS stress-activated MAPK cascade
GO:0051770 IEA positive regulation of nitric-oxide synthase biosynthetic process
GO:0060048 IEA cardiac muscle contraction
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0072709 IEA cellular response to sorbitol

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005567 map2k6 mitogen-activated protein kinase kinase 6 protein_coding Danio_rerio
ENSMUSG00000020623 Map2k6 mitogen-activated protein kinase kinase 6 protein_coding Mus_musculus

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