C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mitogen-activated protein kinase kinase 6
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000590474 MAP2K6-001 ENSG00000108984 9606 + 17:69414698-69543331 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonKidneyLiverLungOvaryPlacentaENST00000590474
Transcript ID Bladder Brain Breast Colon Kidney Liver Lung Ovary Placenta
ENST00000590474 1.410±0.00 0.699±0.18 0.317±0.06 2.012±0.00 0.310±0.00 0.632±0.00 0.240±0.00 0.564±0.22 0.179±0.10

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006H0 CIL_0006H0_0001 CGP 17:69244311-69543331
CIL_00072F CIL_00072F_0001 CGP 17:69414698-70135608

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000187 TAS activation of MAPK activity
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0002931 IEA response to ischemia
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IEA MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0006975 TAS DNA damage induced protein phosphorylation
GO:0007050 TAS cell cycle arrest
GO:0007165 TAS signal transduction
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0022602 IEA ovulation cycle process
GO:0032308 IEA positive regulation of prostaglandin secretion
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042493 IEA response to drug
GO:0042692 TAS muscle cell differentiation
GO:0043065 IEA positive regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0051149 TAS positive regulation of muscle cell differentiation
GO:0051403 TAS stress-activated MAPK cascade
GO:0051770 IEA positive regulation of nitric-oxide synthase biosynthetic process
GO:0060048 IEA cardiac muscle contraction
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0072709 IEA cellular response to sorbitol

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000020949 Map2k6-001 protein_coding Mus_musculus 0 2346
ENSMUST00000100260 Map2k6-003 protein_coding Mus_musculus 0 1692
ENSMUST00000146084 Map2k6-002 processed_transcript Mus_musculus 0 1465
ENSMUST00000146540 Map2k6-005 processed_transcript Mus_musculus 0 1160
ENSMUST00000133920 Map2k6-004 processed_transcript Mus_musculus 0 935

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