C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020623 Map2k6 10090 + 11:110399122-110525522 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000020949 Map2k6-001 110399122-110513641 protein_coding
  ENSMUST00000100260 Map2k6-003 110399122-110525522 protein_coding
  ENSMUST00000133920 Map2k6-004 110479039-110497926 processed_transcript
  ENSMUST00000146084 Map2k6-002 110399259-110513641 processed_transcript
  ENSMUST00000146540 Map2k6-005 110477377-110499522 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000020949ENSMUST00000100260ENSMUST00000133920ENSMUST00000146084ENSMUST00000146540
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000020949 2.712±1.10 0.381±0.14 3.095±0.28 4.242±1.91 1.051±0.50 1.987±0.61 1.491±0.42 3.020±0.60 1.812±1.25 1.283±0.36 7.036±1.08 1.555±0.78 4.230±2.21 0.273±0.11
ENSMUST00000100260 N/A N/A N/A N/A N/A N/A N/A N/A 0.136±0.00 N/A N/A 0.341±0.00 N/A 0.078±0.00
ENSMUST00000133920 N/A N/A N/A N/A N/A 0.650±0.00 0.419±0.00 0.782±0.00 0.516±0.10 N/A N/A 0.286±0.00 N/A N/A
ENSMUST00000146084 N/A 0.224±0.07 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.228±0.15 N/A 0.076±0.00
ENSMUST00000146540 1.309±0.51 0.421±0.02 N/A N/A 0.818±0.33 2.012±0.80 1.084±0.33 1.519±0.41 1.353±0.38 0.951±0.42 N/A 1.479±0.45 2.599±0.00 0.274±0.08

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006H0 CIL_0006H0_0002 CGP 11:110269369-110525522
CIL_00072F CIL_00072F_0002 CGP 11:110399122-111027968

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IPI MAPK cascade
GO:0000187 IMP activation of MAPK activity
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002931 IEA response to ischemia
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IEA MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IDA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0022602 IEA ovulation cycle process
GO:0032308 IEA positive regulation of prostaglandin secretion
GO:0042493 IEA response to drug
GO:0043065 IEA positive regulation of apoptotic process
GO:0051770 IEA positive regulation of nitric-oxide synthase biosynthetic process
GO:0060048 IMP cardiac muscle contraction
GO:0072709 IEA cellular response to sorbitol

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005567 map2k6 mitogen-activated protein kinase kinase 6 protein_coding Danio_rerio
ENSG00000108984 MAP2K6 mitogen-activated protein kinase kinase 6 protein_coding Homo_sapiens

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