C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MAP-kinase activating death domain
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000110514 MADD 9606 + 11:47269161-47330031 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000311027 MADD-006 47269674-47330031 protein_coding
  ENST00000342922 MADD-001 47269376-47330031 protein_coding
  ENST00000349238 MADD-005 47269674-47330031 protein_coding
  ENST00000395336 MADD-004 47270148-47330031 protein_coding
  ENST00000395344 MADD-023 47269684-47329357 protein_coding
  ENST00000402192 MADD-009 47270156-47330030 protein_coding
  ENST00000402799 MADD-002 47269674-47330031 protein_coding
  ENST00000405573 MADD-018 47292527-47325035 protein_coding
  ENST00000406482 MADD-003 47269674-47330031 protein_coding
  ENST00000407859 MADD-007 47269674-47330031 protein_coding
  ENST00000422579 MADD-013 47272244-47274905 protein_coding
  ENST00000428807 MADD-012 47269672-47278198 protein_coding
  ENST00000444117 MADD-011 47269693-47274909 protein_coding
  ENST00000453571 MADD-010 47269161-47274726 protein_coding
  ENST00000460452 MADD-015 47323671-47327186 retained_intron
  ENST00000469699 MADD-017 47328142-47329406 retained_intron
  ENST00000489415 MADD-014 47276028-47282595 processed_transcript
  ENST00000494403 MADD-016 47324298-47325296 processed_transcript
  ENST00000524530 MADD-022 47284946-47290069 processed_transcript
  ENST00000524686 MADD-021 47285271-47289921 processed_transcript
  ENST00000526603 MADD-020 47270156-47275005 processed_transcript
  ENST00000534808 MADD-019 47269677-47274997 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000342922ENST00000349238ENST00000395336ENST00000395344ENST00000402192ENST00000402799ENST00000405573ENST00000406482ENST00000407859ENST00000460452
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000342922 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.818±0.00 N/A
ENST00000349238 N/A N/A N/A N/A N/A 1.389±0.00 N/A N/A N/A 1.181±0.46 N/A N/A N/A N/A
ENST00000395336 N/A N/A N/A 7.472±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000395344 1.196±0.00 N/A N/A 3.167±0.00 N/A N/A 0.550±0.00 N/A 1.498±0.00 1.322±0.00 N/A 0.901±0.00 1.671±0.00 4.113±0.00
ENST00000402192 3.240±0.00 2.101±0.00 0.434±0.00 5.710±0.00 0.832±0.22 1.621±0.56 N/A 2.713±0.00 N/A 3.229±0.00 N/A 3.276±1.49 N/A 7.007±3.06
ENST00000402799 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.053±0.64 3.131±0.75 N/A
ENST00000405573 N/A N/A N/A N/A N/A 2.584±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000406482 N/A N/A 0.705±0.00 4.815±0.00 N/A 1.119±0.00 N/A N/A N/A N/A 1.948±0.00 1.533±0.00 1.384±0.22 N/A
ENST00000407859 1.057±0.00 N/A N/A N/A 0.640±0.00 1.221±0.00 N/A N/A N/A N/A 3.030±0.00 2.295±0.57 1.297±0.00 N/A
ENST00000460452 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.221±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IMP activation of MAPK activity
GO:0005123 TAS death receptor binding
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005886 IDA plasma membrane
GO:0007166 TAS cell surface receptor signaling pathway
GO:0016021 IDA integral component of membrane
GO:0017112 IDA Rab guanyl-nucleotide exchange factor activity
GO:0030295 TAS protein kinase activator activity
GO:0032483 IDA regulation of Rab protein signal transduction
GO:0032851 IDA positive regulation of Rab GTPase activity
GO:0042981 IMP regulation of apoptotic process
GO:0051726 IMP regulation of cell cycle
GO:0097194 IMP execution phase of apoptosis
GO:1902041 IMP regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001234 IEA negative regulation of apoptotic signaling pathway
GO:2001236 IDA regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003495 madd MAP-kinase activating death domain protein_coding Danio_rerio
ENSMUSG00000040687 Madd MAP-kinase activating death domain protein_coding Mus_musculus

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