C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: methionyl aminopeptidase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000111142 METAP2 9606 + 12:95473520-95515839 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261220 METAP2-002 95474150-95514342 protein_coding
  ENST00000323666 METAP2-001 95473951-95515839 protein_coding
  ENST00000535095 METAP2-003 95473520-95514342 nonsense_mediated_decay
  ENST00000546478 METAP2-009 95485809-95494114 retained_intron
  ENST00000546753 METAP2-004 95474081-95514299 protein_coding
  ENST00000549136 METAP2-011 95476071-95483494 retained_intron
  ENST00000549502 METAP2-008 95474152-95485954 protein_coding
  ENST00000549808 METAP2-010 95484794-95495149 protein_coding
  ENST00000550777 METAP2-006 95474155-95514329 protein_coding
  ENST00000551840 METAP2-007 95474162-95514326 protein_coding
  ENST00000553151 METAP2-012 95474152-95494974 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261220ENST00000323666ENST00000535095ENST00000546753ENST00000549502ENST00000549808ENST00000550777ENST00000551840ENST00000553151
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261220 N/A N/A N/A N/A 7.250±0.00 9.830±0.00 N/A 1.938±0.00 N/A 4.056±0.00 N/A 23.601±0.00 15.302±0.00 29.675±0.00
ENST00000323666 2.919±0.00 4.272±0.00 0.758±0.00 2.988±0.41 2.297±0.50 1.890±0.00 1.747±0.47 1.319±0.00 2.352±0.47 1.517±0.13 2.428±0.00 6.273±1.98 3.871±1.26 13.127±2.47
ENST00000535095 N/A N/A N/A N/A N/A N/A N/A N/A 2.438±0.00 N/A N/A N/A N/A N/A
ENST00000546753 8.705±0.00 N/A N/A 1.922±0.83 2.387±1.11 6.241±0.00 3.981±0.00 4.453±0.00 4.474±0.00 3.673±0.00 9.372±0.00 5.129±0.00 2.900±0.72 N/A
ENST00000549502 N/A N/A N/A N/A N/A N/A 1.904±0.00 N/A N/A N/A N/A N/A 16.366±0.00 N/A
ENST00000549808 N/A N/A 4.866±0.00 N/A 6.648±0.00 6.350±0.00 N/A N/A N/A N/A N/A 94.012±0.00 64.015±0.00 78.747±0.00
ENST00000550777 N/A 8.708±0.00 N/A 5.713±0.00 4.538±0.00 N/A 6.584±0.00 7.660±0.00 5.670±0.00 5.222±0.00 9.201±0.00 11.960±0.00 6.930±0.29 11.392±0.00
ENST00000551840 9.400±0.00 12.995±0.00 1.428±0.00 3.995±1.38 3.443±1.95 10.169±7.49 4.425±2.91 9.368±6.40 3.639±0.76 3.475±0.94 N/A 10.103±7.37 4.881±1.43 17.466±0.00
ENST00000553151 N/A N/A N/A 12.053±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000Y1 CIL_0000Y1_0002 CGP 12:95217746-95515839
CIL_0000Y2 CIL_0000Y2_0002 CGP 12:95473520-95551490

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004177 IDA:IEA aminopeptidase activity
GO:0005515 IEA protein binding
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006508 IEA proteolysis
GO:0007603 TAS phototransduction, visible light
GO:0008152 IEA metabolic process
GO:0008235 IDA:IEA metalloexopeptidase activity
GO:0016056 TAS rhodopsin mediated signaling pathway
GO:0016485 IDA protein processing
GO:0016787 IEA hydrolase activity
GO:0018206 IDA peptidyl-methionine modification
GO:0022400 TAS regulation of rhodopsin mediated signaling pathway
GO:0031365 IDA N-terminal protein amino acid modification
GO:0044822 IDA poly(A) RNA binding
GO:0046872 IEA metal ion binding
GO:0070006 IEA metalloaminopeptidase activity
GO:0070084 IEA protein initiator methionine removal

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069261 metap2a methionyl aminopeptidase 2a protein_coding Danio_rerio
ENSDARG00000092768 metap2b methionyl aminopeptidase 2b protein_coding Danio_rerio
ENSMUSG00000036112 Metap2 methionine aminopeptidase 2 protein_coding Mus_musculus

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