C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: leukotriene A4 hydrolase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000111144 LTA4H 9606 - 12:96000828-96043520 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000228740 LTA4H-001 96000828-96035661 protein_coding
  ENST00000413268 LTA4H-002 96000907-96043520 protein_coding
  ENST00000537111 LTA4H-009 96000830-96011258 retained_intron
  ENST00000547393 LTA4H-011 96003594-96013252 retained_intron
  ENST00000547982 LTA4H-008 96011295-96015174 retained_intron
  ENST00000548375 LTA4H-010 96006314-96015134 processed_transcript
  ENST00000548852 LTA4H-004 96002990-96035641 nonsense_mediated_decay
  ENST00000552091 LTA4H-012 96013239-96014324 retained_intron
  ENST00000552789 LTA4H-003 96000830-96043477 protein_coding
  ENST00000553041 LTA4H-007 96000833-96035528 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000228740ENST00000413268ENST00000537111ENST00000547982ENST00000548852ENST00000553041
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000228740 8.431±0.00 16.539±0.00 5.893±0.00 4.586±1.31 14.979±11.27 20.327±11.41 4.407±2.84 5.815±0.03 5.206±0.14 34.281±20.74 8.113±3.18 29.344±18.85 15.547±3.11 23.479±0.00
ENST00000413268 N/A N/A 2.626±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 8.593±0.00 N/A N/A
ENST00000537111 N/A N/A 2.308±0.00 N/A N/A N/A N/A N/A 2.018±0.00 N/A N/A N/A N/A N/A
ENST00000547982 N/A N/A N/A N/A N/A N/A N/A N/A 3.594±0.00 N/A N/A N/A N/A N/A
ENST00000548852 N/A N/A N/A 3.801±0.00 6.836±0.00 6.525±0.00 1.936±0.00 5.763±0.00 3.580±0.00 35.547±0.00 N/A 24.107±7.95 N/A N/A
ENST00000553041 N/A 0.831±0.00 0.552±0.00 N/A 0.914±0.00 1.060±0.00 N/A N/A 0.697±0.00 3.631±0.00 N/A N/A N/A 2.586±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006AH CIL_0006AH_0002 CGP 12:96000828-96269835

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004177 IDA aminopeptidase activity
GO:0004301 TAS epoxide hydrolase activity
GO:0004463 IDA:IEA leukotriene-A4 hydrolase activity
GO:0005488 IEA binding
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006508 IEA proteolysis
GO:0006691 TAS leukotriene metabolic process
GO:0006954 NAS inflammatory response
GO:0008233 TAS peptidase activity
GO:0008237 IEA metallopeptidase activity
GO:0008270 IDA:IEA zinc ion binding
GO:0019369 TAS arachidonic acid metabolic process
GO:0019370 IDA:IEA leukotriene biosynthetic process
GO:0043171 IDA peptide catabolic process
GO:0044281 TAS small molecule metabolic process
GO:0044822 IDA poly(A) RNA binding
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006029 lta4h leukotriene A4 hydrolase protein_coding Danio_rerio
ENSMUSG00000015889 Lta4h leukotriene A4 hydrolase protein_coding Mus_musculus

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