C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000111276 CDKN1B 9606 + 12:12715058-12722371 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000228872 CDKN1B-001 12717124-12722371 protein_coding
  ENST00000396340 CDKN1B-003 12717822-12721468 protein_coding
  ENST00000442489 CDKN1B-002 12717861-12721289 protein_coding
  ENST00000477087 CDKN1B-004 12715058-12721204 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000228872ENST00000396340ENST00000442489
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000228872 27.098±0.00 17.943±0.00 3.066±0.00 23.414±13.32 11.727±7.26 23.472±17.23 6.717±4.50 9.627±4.59 7.985±1.94 24.416±18.70 14.520±13.60 24.217±6.83 19.641±1.09 15.635±9.28
ENST00000396340 N/A N/A N/A 16.386±0.00 N/A N/A N/A N/A N/A N/A N/A 13.959±0.00 N/A N/A
ENST00000442489 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15.607±0.00 14.218±0.00 13.505±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000KC CIL_0000KC_0001 CGP 12:12660891-12722371
CIL_0000KD CIL_0000KD_0001 CGP 12:12715058-12829975

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000079 TAS regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 IDA G1/S transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0001666 IEA response to hypoxia
GO:0004861 IEA cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005072 TAS transforming growth factor beta receptor, cytoplasmic mediator activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005829 TAS cytosol
GO:0006813 IEA potassium ion transport
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050 IMP:IEA cell cycle arrest
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007605 IEA sensory perception of sound
GO:0008219 IEA cell death
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0008656 IDA cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0009749 IEA response to glucose
GO:0010942 IDA positive regulation of cell death
GO:0014070 IEA response to organic cyclic compound
GO:0019903 IPI protein phosphatase binding
GO:0030308 IDA negative regulation of cell growth
GO:0030544 IEA Hsp70 protein binding
GO:0031116 IEA positive regulation of microtubule polymerization
GO:0032355 IEA response to estradiol
GO:0032403 IEA protein complex binding
GO:0033673 IDA negative regulation of kinase activity
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042326 IDA negative regulation of phosphorylation
GO:0042493 IEA response to drug
GO:0043066 IEA negative regulation of apoptotic process
GO:0043200 IEA response to amino acid
GO:0043234 IEA protein complex
GO:0043434 IEA response to peptide hormone
GO:0045087 TAS innate immune response
GO:0045732 IDA positive regulation of protein catabolic process
GO:0045736 IEA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045930 IDA negative regulation of mitotic cell cycle
GO:0046686 IEA response to cadmium ion
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048102 IDA autophagic cell death
GO:0048839 IEA inner ear development
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0051087 IEA chaperone binding
GO:0051271 IEA negative regulation of cellular component movement
GO:0060770 IEA negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071236 IEA cellular response to antibiotic
GO:0071285 IDA cellular response to lithium ion
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071850 IDA mitotic cell cycle arrest
GO:0071901 IEA negative regulation of protein serine/threonine kinase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029018 cdkn1ba cyclin-dependent kinase inhibitor 1Ba protein_coding Danio_rerio
ENSDARG00000054271 cdkn1bb cyclin-dependent kinase inhibitor 1Bb protein_coding Danio_rerio
ENSDARG00000088081 cdkn1bb cyclin-dependent kinase inhibitor 1Bb protein_coding Danio_rerio
ENSMUSG00000003031 Cdkn1b cyclin-dependent kinase inhibitor 1B protein_coding Mus_musculus

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