C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cyclin-dependent kinase inhibitor 1B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000003031 Cdkn1b 10090 + 6:134920401-134925513 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000003115 Cdkn1b-002 134920401-134925513 protein_coding
  ENSMUST00000067327 Cdkn1b-001 134920401-134925513 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000003115ENSMUST00000067327
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000003115 11.492±4.45 36.208±2.52 11.953±0.43 13.390±7.64 27.090±10.61 26.432±4.92 6.786±2.17 14.098±2.16 8.007±1.70 23.636±3.17 10.410±0.47 35.329±7.88 9.067±2.09 2.035±0.80
ENSMUST00000067327 3.684±1.68 N/A 3.835±0.33 3.646±1.72 3.638±0.96 3.398±0.59 1.887±0.34 2.147±0.27 2.641±1.68 5.092±1.16 2.594±0.74 7.002±6.17 2.134±0.92 0.473±0.17

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000KC CIL_0000KC_0002 CGP 6:134869093-134925513
CIL_0000KD CIL_0000KD_0002 CGP 6:134920401-134986836

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IDA G1/S transition of mitotic cell cycle
GO:0001666 IEA response to hypoxia
GO:0004861 IDA cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005829 IDA cytosol
GO:0006813 IGI potassium ion transport
GO:0006919 IEA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007050 IDA cell cycle arrest
GO:0007605 IMP sensory perception of sound
GO:0008219 IEA cell death
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IMP negative regulation of cell proliferation
GO:0008656 IEA cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0009749 IEA response to glucose
GO:0010942 IEA positive regulation of cell death
GO:0014070 IEA response to organic cyclic compound
GO:0019903 IEA protein phosphatase binding
GO:0030308 IEA negative regulation of cell growth
GO:0030544 IEA Hsp70 protein binding
GO:0031116 IGI positive regulation of microtubule polymerization
GO:0032355 IEA response to estradiol
GO:0032403 IEA protein complex binding
GO:0033673 IEA negative regulation of kinase activity
GO:0042326 IEA negative regulation of phosphorylation
GO:0042493 IEA response to drug
GO:0043066 IMP negative regulation of apoptotic process
GO:0043200 IEA response to amino acid
GO:0043234 IEA protein complex
GO:0043434 IEA response to peptide hormone
GO:0045732 IEA positive regulation of protein catabolic process
GO:0045736 IDA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045930 IEA negative regulation of mitotic cell cycle
GO:0046686 IEA response to cadmium ion
GO:0048102 IEA autophagic cell death
GO:0048839 IMP inner ear development
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0051087 IEA chaperone binding
GO:0051271 IDA negative regulation of cellular component movement
GO:0060770 IMP negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071236 IDA cellular response to antibiotic
GO:0071285 ISO cellular response to lithium ion
GO:0071407 IDA cellular response to organic cyclic compound
GO:0071850 IEA mitotic cell cycle arrest

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029018 cdkn1ba cyclin-dependent kinase inhibitor 1Ba protein_coding Danio_rerio
ENSDARG00000054271 cdkn1bb cyclin-dependent kinase inhibitor 1Bb protein_coding Danio_rerio
ENSDARG00000088081 cdkn1bb cyclin-dependent kinase inhibitor 1Bb protein_coding Danio_rerio
ENSG00000111276 CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) protein_coding Homo_sapiens

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