C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase 14
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000112062 MAPK14 9606 + 6:36027677-36111236 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000229794 MAPK14-002 36027770-36110755 protein_coding
  ENST00000229795 MAPK14-001 36027711-36111236 protein_coding
  ENST00000310795 MAPK14-004 36028158-36108509 protein_coding
  ENST00000468133 MAPK14-003 36027782-36108670 protein_coding
  ENST00000472333 MAPK14-007 36029089-36076555 protein_coding
  ENST00000474429 MAPK14-008 36028199-36107529 nonsense_mediated_decay
  ENST00000490379 MAPK14-009 36075865-36076888 retained_intron
  ENST00000491957 MAPK14-006 36028158-36098054 nonsense_mediated_decay
  ENST00000496250 MAPK14-005 36028158-36098054 retained_intron
  ENST00000622903 MAPK14-201 36027677-36075847 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000229794ENST00000229795ENST00000468133ENST00000496250
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000229794 9.594±0.00 5.889±0.00 1.159±0.00 3.425±0.00 5.208±3.15 8.270±3.13 3.659±2.56 5.756±3.89 5.352±2.83 5.464±2.63 3.773±2.46 7.422±3.28 15.444±3.10 5.068±2.36
ENST00000229795 N/A 2.036±0.00 N/A 1.804±0.90 N/A 1.386±0.00 0.848±0.17 2.588±1.42 1.826±0.00 2.256±0.00 N/A 4.240±1.04 4.731±2.49 1.213±0.00
ENST00000468133 N/A N/A N/A 2.846±0.00 6.021±0.00 N/A N/A 3.455±0.00 6.089±0.00 N/A 1.421±0.00 5.442±0.00 N/A N/A
ENST00000496250 N/A N/A N/A N/A N/A 2.960±0.00 0.871±0.00 N/A N/A N/A 0.509±0.00 2.598±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002O8 CIL_0002O8_0001 CGP 6:35943514-36111236
CIL_0002O5 CIL_0002O5_0001 CGP 6:36027677-36144524

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000077 IEA DNA damage checkpoint
GO:0000165 IEA MAPK cascade
GO:0000187 TAS activation of MAPK activity
GO:0000902 IEA cell morphogenesis
GO:0000922 IEA spindle pole
GO:0001502 IEA cartilage condensation
GO:0001525 IEA angiogenesis
GO:0002062 IEA chondrocyte differentiation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 TAS protein serine/threonine kinase activity
GO:0004707 IEA:IDA MAP kinase activity
GO:0004708 TAS MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005623 IEA cell
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0006006 IEA glucose metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 ISS regulation of transcription from RNA polymerase II promoter
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0006928 TAS cellular component movement
GO:0006935 TAS chemotaxis
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007165 TAS signal transduction
GO:0007166 TAS cell surface receptor signaling pathway
GO:0007178 IEA transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007265 TAS Ras protein signal transduction
GO:0007519 IEA skeletal muscle tissue development
GO:0007596 TAS blood coagulation
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0010467 TAS gene expression
GO:0010831 ISS positive regulation of myotube differentiation
GO:0014835 IEA myoblast differentiation involved in skeletal muscle regeneration
GO:0016020 IEA membrane
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016301 IEA kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 ISS peptidyl-serine phosphorylation
GO:0019395 IEA fatty acid oxidation
GO:0030168 TAS platelet activation
GO:0030316 ISS osteoclast differentiation
GO:0031663 IEA lipopolysaccharide-mediated signaling pathway
GO:0032495 IEA response to muramyl dipeptide
GO:0032496 IEA response to lipopolysaccharide
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035556 IDA intracellular signal transduction
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035924 IMP cellular response to vascular endothelial growth factor stimulus
GO:0038066 ISS p38MAPK cascade
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042307 IEA positive regulation of protein import into nucleus
GO:0042692 TAS muscle cell differentiation
GO:0042770 IMP signal transduction in response to DNA damage
GO:0045087 TAS innate immune response
GO:0045648 IEA positive regulation of erythrocyte differentiation
GO:0045663 ISS positive regulation of myoblast differentiation
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048010 IMP vascular endothelial growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051090 TAS regulation of sequence-specific DNA binding transcription factor activity
GO:0051146 IEA striated muscle cell differentiation
GO:0051149 TAS positive regulation of muscle cell differentiation
GO:0051403 TAS stress-activated MAPK cascade
GO:0051525 ISS NFAT protein binding
GO:0070062 IDA extracellular vesicular exosome
GO:0070935 TAS 3'-UTR-mediated mRNA stabilization
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0071479 IMP cellular response to ionizing radiation
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:0090336 IEA positive regulation of brown fat cell differentiation
GO:0090400 IMP stress-induced premature senescence
GO:1901741 ISS positive regulation of myoblast fusion
GO:2000379 IMP positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000000857 mapk14a mitogen-activated protein kinase 14a protein_coding Danio_rerio
ENSDARG00000028721 mapk14b mitogen-activated protein kinase 14b protein_coding Danio_rerio
ENSMUSG00000053436 Mapk14 mitogen-activated protein kinase 14 protein_coding Mus_musculus

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