C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase 14
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000053436 Mapk14 10090 + 17:28691342-28748404 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000004990 Mapk14-001 28691342-28748404 protein_coding
  ENSMUST00000062694 Mapk14-002 28691342-28748404 protein_coding
  ENSMUST00000114752 Mapk14-005 28692568-28748404 protein_coding
  ENSMUST00000114754 Mapk14-003 28691342-28748404 protein_coding
  ENSMUST00000114758 Mapk14-004 28691342-28741164 protein_coding
  ENSMUST00000124886 Mapk14-006 28691440-28728471 protein_coding
  ENSMUST00000151613 Mapk14-007 28741619-28746357 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000004990ENSMUST00000062694ENSMUST00000114752ENSMUST00000114758ENSMUST00000124886
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000004990 6.901±0.69 5.973±0.46 5.404±0.00 14.242±0.98 9.930±2.54 7.781±0.67 N/A 7.445±1.46 6.198±2.79 7.079±0.04 N/A 9.676±3.17 7.565±1.62 1.503±0.47
ENSMUST00000062694 19.982±8.57 33.954±3.93 16.871±5.07 N/A 29.198±12.33 31.349±3.49 8.978±1.25 22.842±2.14 16.198±5.47 35.022±8.88 27.119±11.44 33.426±4.34 19.342±7.56 2.064±0.27
ENSMUST00000114752 16.010±2.34 N/A 21.535±8.45 5.897±1.35 28.706±7.86 N/A 16.069±2.67 14.766±1.58 12.989±3.17 18.376±1.72 5.079±0.00 13.015±3.86 20.109±5.86 1.619±1.34
ENSMUST00000114758 N/A 17.586±7.19 N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.839±0.00 N/A N/A
ENSMUST00000124886 N/A N/A N/A 20.124±0.00 N/A N/A N/A N/A N/A N/A N/A 18.007±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002O8 CIL_0002O8_0002 CGP 17:28637783-28748404
CIL_0002O5 CIL_0002O5_0002 CGP 17:28691342-28778698

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000077 IMP DNA damage checkpoint
GO:0000165 IEA MAPK cascade
GO:0000902 IGI cell morphogenesis
GO:0000922 IDA spindle pole
GO:0001502 IMP cartilage condensation
GO:0001525 IMP angiogenesis
GO:0002062 IDA:IMP chondrocyte differentiation
GO:0004672 IDA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004707 IDA:ISS MAP kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005623 IDA cell
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005829 IDA cytosol
GO:0006006 IMP glucose metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IMP regulation of transcription from RNA polymerase II promoter
GO:0006468 IDA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007178 IGI transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007519 IMP skeletal muscle tissue development
GO:0010831 IMP positive regulation of myotube differentiation
GO:0014835 IMP myoblast differentiation involved in skeletal muscle regeneration
GO:0016301 IDA kinase activity
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019395 IMP fatty acid oxidation
GO:0030316 IMP osteoclast differentiation
GO:0031663 IDA lipopolysaccharide-mediated signaling pathway
GO:0032495 IDA response to muramyl dipeptide
GO:0032496 IDA response to lipopolysaccharide
GO:0035556 ISS intracellular signal transduction
GO:0035924 IEA cellular response to vascular endothelial growth factor stimulus
GO:0038066 IDA p38MAPK cascade
GO:0042307 IMP positive regulation of protein import into nucleus
GO:0042770 IEA signal transduction in response to DNA damage
GO:0045648 IMP positive regulation of erythrocyte differentiation
GO:0045663 IMP positive regulation of myoblast differentiation
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0048010 IEA vascular endothelial growth factor receptor signaling pathway
GO:0051146 IGI striated muscle cell differentiation
GO:0051525 IPI NFAT protein binding
GO:0070062 IEA extracellular vesicular exosome
GO:0071222 ISO cellular response to lipopolysaccharide
GO:0071479 IEA cellular response to ionizing radiation
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway
GO:0090336 IMP positive regulation of brown fat cell differentiation
GO:0090400 IEA stress-induced premature senescence
GO:1901741 IMP positive regulation of myoblast fusion
GO:2000379 IEA positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000000857 mapk14a mitogen-activated protein kinase 14a protein_coding Danio_rerio
ENSDARG00000028721 mapk14b mitogen-activated protein kinase 14b protein_coding Danio_rerio
ENSG00000112062 MAPK14 mitogen-activated protein kinase 14 protein_coding Homo_sapiens

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