C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mitogen-activated protein kinase 14
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000229794 MAPK14-002 ENSG00000112062 9606 + 6:36027770-36110755 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000229794
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000229794 9.594±0.00 5.889±0.00 1.159±0.00 3.425±0.00 5.208±3.15 8.270±3.13 3.659±2.56 5.756±3.89 5.352±2.83 5.464±2.63 3.773±2.46 7.422±3.28 15.444±3.10 5.068±2.36

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002O8 CIL_0002O8_0001 CGP 6:35943514-36111236
CIL_0002O5 CIL_0002O5_0001 CGP 6:36027677-36144524

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000187 TAS activation of MAPK activity
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 TAS protein serine/threonine kinase activity
GO:0004707 IEA:IDA MAP kinase activity
GO:0004708 TAS MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006357 ISS regulation of transcription from RNA polymerase II promoter
GO:0006468 IEA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0006928 TAS cellular component movement
GO:0006935 TAS chemotaxis
GO:0007165 TAS signal transduction
GO:0007166 TAS cell surface receptor signaling pathway
GO:0007265 TAS Ras protein signal transduction
GO:0007596 TAS blood coagulation
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0010467 TAS gene expression
GO:0010831 ISS positive regulation of myotube differentiation
GO:0016020 IEA membrane
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 ISS peptidyl-serine phosphorylation
GO:0030168 TAS platelet activation
GO:0030316 ISS osteoclast differentiation
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035556 IDA intracellular signal transduction
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0035924 IMP cellular response to vascular endothelial growth factor stimulus
GO:0038066 ISS p38MAPK cascade
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0042692 TAS muscle cell differentiation
GO:0042770 IMP signal transduction in response to DNA damage
GO:0045087 TAS innate immune response
GO:0045663 ISS positive regulation of myoblast differentiation
GO:0048010 IMP vascular endothelial growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051090 TAS regulation of sequence-specific DNA binding transcription factor activity
GO:0051149 TAS positive regulation of muscle cell differentiation
GO:0051403 TAS stress-activated MAPK cascade
GO:0051525 ISS NFAT protein binding
GO:0070062 IDA extracellular vesicular exosome
GO:0070935 TAS 3'-UTR-mediated mRNA stabilization
GO:0071222 IDA cellular response to lipopolysaccharide
GO:0071479 IMP cellular response to ionizing radiation
GO:0090400 IMP stress-induced premature senescence
GO:1901741 ISS positive regulation of myoblast fusion
GO:2000379 IMP positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000062694 Mapk14-002 protein_coding Mus_musculus 0 1642
ENSMUST00000004990 Mapk14-001 protein_coding Mus_musculus 0 1432
ENSMUST00000114752 Mapk14-005 protein_coding Mus_musculus 0 1421
ENSMUST00000114754 Mapk14-003 protein_coding Mus_musculus 0 1421
ENSMUST00000114758 Mapk14-004 protein_coding Mus_musculus 0 1026
ENSMUST00000124886 Mapk14-006 protein_coding Mus_musculus 0 769
ENSMUST00000151613 Mapk14-007 retained_intron Mus_musculus 0 484
ENSMUST00000004986 Mapk13-001 protein_coding Mus_musculus 0 196
ENSMUST00000129096 Mapk13-002 nonsense_mediated_decay Mus_musculus 2e-39 169

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