C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: wingless-type MMTV integration site family, member 5A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000114251 WNT5A 9606 - 3:55465715-55490539 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264634 WNT5A-201 55465716-55487642 protein_coding
  ENST00000474267 WNT5A-001 55465715-55489945 protein_coding
  ENST00000482079 WNT5A-009 55474334-55481196 protein_coding
  ENST00000493406 WNT5A-007 55469388-55470141 processed_transcript
  ENST00000497027 WNT5A-005 55469993-55481393 protein_coding
  ENST00000497817 WNT5A-008 55479040-55480920 retained_intron
  ENST00000614415 WNT5A-202 55470042-55481363 protein_coding
  ENST00000624674 WNT5A-010 55489155-55490539 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264634ENST00000474267ENST00000497027ENST00000624674
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264634 0.103±0.00 0.590±0.00 0.472±0.00 0.419±0.13 0.201±0.00 0.753±0.57 0.570±0.00 0.820±0.00 0.965±0.00 0.563±0.00 N/A 2.612±1.18 1.333±0.00 1.123±0.00
ENST00000474267 0.095±0.00 N/A N/A N/A 0.200±0.00 0.512±0.00 0.474±0.00 0.828±0.00 N/A 0.175±0.00 0.160±0.00 0.598±0.00 1.359±0.00 0.648±0.00
ENST00000497027 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.265±0.00 N/A N/A 1.112±0.00
ENST00000624674 N/A N/A N/A N/A N/A N/A N/A 0.337±0.00 N/A 0.036±0.00 N/A 0.084±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00083K CIL_00083K_0001 VISTA 3:55190515-55792232
CIL_0007P0 CIL_0007P0_0001 UCNEbase 3:55244350-55755999

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IDA activation of MAPK activity
GO:0001667 IEA ameboidal cell migration
GO:0001736 IEA establishment of planar polarity
GO:0001756 IEA somitogenesis
GO:0001837 IEP epithelial to mesenchymal transition
GO:0001843 IEA neural tube closure
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0001938 IMP positive regulation of endothelial cell proliferation
GO:0001947 IEA heart looping
GO:0002009 IEA morphogenesis of an epithelium
GO:0002053 IEA positive regulation of mesenchymal cell proliferation
GO:0002088 ISS lens development in camera-type eye
GO:0002741 IMP positive regulation of cytokine secretion involved in immune response
GO:0003323 IEA type B pancreatic cell development
GO:0003344 IEA pericardium morphogenesis
GO:0003401 IEA axis elongation
GO:0003408 ISS optic cup formation involved in camera-type eye development
GO:0003700 IMP sequence-specific DNA binding transcription factor activity
GO:0005102 IEA receptor binding
GO:0005109 IPI frizzled binding
GO:0005110 IEA frizzled-2 binding
GO:0005115 IPI receptor tyrosine kinase-like orphan receptor binding
GO:0005125 IEA cytokine activity
GO:0005515 IEA protein binding
GO:0005576 TAS:IEA extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IDA extracellular space
GO:0005788 TAS endoplasmic reticulum lumen
GO:0005796 TAS Golgi lumen
GO:0005886 TAS plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007223 IMP Wnt signaling pathway, calcium modulating pathway
GO:0007254 IEA JNK cascade
GO:0007257 IMP activation of JUN kinase activity
GO:0007275 IEA multicellular organismal development
GO:0007368 IEA determination of left/right symmetry
GO:0007411 ISS axon guidance
GO:0007442 IEA hindgut morphogenesis
GO:0007494 IEA midgut development
GO:0008284 IEA positive regulation of cell proliferation
GO:0008584 IEP male gonad development
GO:0008595 IEA anterior/posterior axis specification, embryo
GO:0009952 IEA anterior/posterior pattern specification
GO:0009986 IEA cell surface
GO:0010033 IEP response to organic substance
GO:0010595 IMP positive regulation of endothelial cell migration
GO:0010800 IEA positive regulation of peptidyl-threonine phosphorylation
GO:0010820 IMP positive regulation of T cell chemotaxis
GO:0010976 ISS positive regulation of neuron projection development
GO:0016055 IDA:IEA Wnt signaling pathway
GO:0016477 IEA cell migration
GO:0019904 IEA protein domain specific binding
GO:0021891 ISS olfactory bulb interneuron development
GO:0021915 IEA neural tube development
GO:0030182 ISS neuron differentiation
GO:0030216 IEP keratinocyte differentiation
GO:0030324 IEA lung development
GO:0030326 IEA embryonic limb morphogenesis
GO:0030514 IEA negative regulation of BMP signaling pathway
GO:0030669 TAS clathrin-coated endocytic vesicle membrane
GO:0030825 IDA positive regulation of cGMP metabolic process
GO:0031012 IEA extracellular matrix
GO:0032148 IDA activation of protein kinase B activity
GO:0032729 IEA positive regulation of interferon-gamma production
GO:0032755 IMP positive regulation of interleukin-6 production
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0034613 IDA cellular protein localization
GO:0035108 IEA limb morphogenesis
GO:0036342 IEA post-anal tail morphogenesis
GO:0038031 IEA non-canonical Wnt signaling pathway via JNK cascade
GO:0040037 IEA negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042060 IDA wound healing
GO:0042472 IEA inner ear morphogenesis
GO:0042733 IEA embryonic digit morphogenesis
GO:0043032 IMP positive regulation of macrophage activation
GO:0043066 IDA negative regulation of apoptotic process
GO:0043507 IEA positive regulation of JUN kinase activity
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045080 IMP positive regulation of chemokine biosynthetic process
GO:0045165 IBA cell fate commitment
GO:0045599 IMP negative regulation of fat cell differentiation
GO:0045732 IGI positive regulation of protein catabolic process
GO:0045766 IMP positive regulation of angiogenesis
GO:0045778 IMP positive regulation of ossification
GO:0045836 IEA positive regulation of meiosis
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IEA positive regulation of JNK cascade
GO:0046546 IEA development of primary male sexual characteristics
GO:0048018 IC receptor agonist activity
GO:0048146 IDA positive regulation of fibroblast proliferation
GO:0048546 IEA digestive tract morphogenesis
GO:0048706 IMP embryonic skeletal system development
GO:0048806 IMP genitalia development
GO:0048812 IEA neuron projection morphogenesis
GO:0048843 IEA negative regulation of axon extension involved in axon guidance
GO:0048850 IEA hypophysis morphogenesis
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0050718 IMP positive regulation of interleukin-1 beta secretion
GO:0050729 IMP positive regulation of inflammatory response
GO:0050919 IEA negative chemotaxis
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051216 IEA cartilage development
GO:0051964 IEA negative regulation of synapse assembly
GO:0060021 IMP palate development
GO:0060026 IEA convergent extension
GO:0060029 IEA convergent extension involved in organogenesis
GO:0060065 IEA uterus development
GO:0060067 IEA cervix development
GO:0060068 IEA vagina development
GO:0060070 IEA canonical Wnt signaling pathway
GO:0060071 IEA Wnt signaling pathway, planar cell polarity pathway
GO:0060157 IEA urinary bladder development
GO:0060324 IMP face development
GO:0060340 IDA positive regulation of type I interferon-mediated signaling pathway
GO:0060599 IEA lateral sprouting involved in mammary gland duct morphogenesis
GO:0060606 IEA tube closure
GO:0060638 IEA mesenchymal-epithelial cell signaling
GO:0060686 IEA negative regulation of prostatic bud formation
GO:0060744 IEA mammary gland branching involved in thelarche
GO:0060750 IEA epithelial cell proliferation involved in mammary gland duct elongation
GO:0060760 IDA positive regulation of response to cytokine stimulus
GO:0060762 IEA regulation of branching involved in mammary gland duct morphogenesis
GO:0060907 IMP positive regulation of macrophage cytokine production
GO:0061036 IEA positive regulation of cartilage development
GO:0061347 IEA planar cell polarity pathway involved in outflow tract morphogenesis
GO:0061348 IEA planar cell polarity pathway involved in ventricular septum morphogenesis
GO:0061349 IEA planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:0061350 IEA planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:0061354 IEA planar cell polarity pathway involved in pericardium morphogenesis
GO:0070062 TAS extracellular vesicular exosome
GO:0070245 IEA positive regulation of thymocyte apoptotic process
GO:0071219 IEA cellular response to molecule of bacterial origin
GO:0071222 IEP cellular response to lipopolysaccharide
GO:0071277 IEP cellular response to calcium ion
GO:0071300 ISS cellular response to retinoic acid
GO:0071346 IEP cellular response to interferon-gamma
GO:0071425 IDA hematopoietic stem cell proliferation
GO:0071542 IEA dopaminergic neuron differentiation
GO:0071560 IEP cellular response to transforming growth factor beta stimulus
GO:0072201 IDA negative regulation of mesenchymal cell proliferation
GO:0090009 IEA primitive streak formation
GO:0090037 IMP positive regulation of protein kinase C signaling
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway
GO:0090103 IEA cochlea morphogenesis
GO:0090179 IEA planar cell polarity pathway involved in neural tube closure
GO:2000049 IEA positive regulation of cell-cell adhesion mediated by cadherin
GO:2000484 IEA positive regulation of interleukin-8 secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014495 wnt5a wingless-type MMTV integration site family, member 5a protein_coding Danio_rerio
ENSMUSG00000021994 Wnt5a wingless-type MMTV integration site family, member 5A protein_coding Mus_musculus

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