C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: wingless-type MMTV integration site family, member 5A
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000474267 WNT5A-001 ENSG00000114251 9606 - 3:55465715-55489945 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000474267
Transcript ID Adipose Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000474267 0.095±0.00 0.200±0.00 0.512±0.00 0.474±0.00 0.828±0.00 0.175±0.00 0.160±0.00 0.598±0.00 1.359±0.00 0.648±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00083K CIL_00083K_0001 VISTA 3:55190515-55792232
CIL_0007P0 CIL_0007P0_0001 UCNEbase 3:55244350-55755999

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000187 IDA activation of MAPK activity
GO:0001837 IEP epithelial to mesenchymal transition
GO:0001938 IMP positive regulation of endothelial cell proliferation
GO:0002088 ISS lens development in camera-type eye
GO:0002741 IMP positive regulation of cytokine secretion involved in immune response
GO:0003408 ISS optic cup formation involved in camera-type eye development
GO:0003700 IMP sequence-specific DNA binding transcription factor activity
GO:0005102 IEA receptor binding
GO:0005109 IPI frizzled binding
GO:0005115 IPI receptor tyrosine kinase-like orphan receptor binding
GO:0005576 TAS:IEA extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IDA extracellular space
GO:0005788 TAS endoplasmic reticulum lumen
GO:0005796 TAS Golgi lumen
GO:0005886 TAS plasma membrane
GO:0007223 IMP Wnt signaling pathway, calcium modulating pathway
GO:0007257 IMP activation of JUN kinase activity
GO:0007275 IEA multicellular organismal development
GO:0007411 ISS axon guidance
GO:0008584 IEP male gonad development
GO:0010033 IEP response to organic substance
GO:0010595 IMP positive regulation of endothelial cell migration
GO:0010820 IMP positive regulation of T cell chemotaxis
GO:0010976 ISS positive regulation of neuron projection development
GO:0016055 IDA:IEA Wnt signaling pathway
GO:0021891 ISS olfactory bulb interneuron development
GO:0030182 ISS neuron differentiation
GO:0030216 IEP keratinocyte differentiation
GO:0030669 TAS clathrin-coated endocytic vesicle membrane
GO:0030825 IDA positive regulation of cGMP metabolic process
GO:0032148 IDA activation of protein kinase B activity
GO:0032755 IMP positive regulation of interleukin-6 production
GO:0034613 IDA cellular protein localization
GO:0042060 IDA wound healing
GO:0043032 IMP positive regulation of macrophage activation
GO:0043066 IDA negative regulation of apoptotic process
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045080 IMP positive regulation of chemokine biosynthetic process
GO:0045165 IBA cell fate commitment
GO:0045599 IMP negative regulation of fat cell differentiation
GO:0045732 IGI positive regulation of protein catabolic process
GO:0045766 IMP positive regulation of angiogenesis
GO:0045778 IMP positive regulation of ossification
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0048018 IC receptor agonist activity
GO:0048146 IDA positive regulation of fibroblast proliferation
GO:0048706 IMP embryonic skeletal system development
GO:0048806 IMP genitalia development
GO:0050718 IMP positive regulation of interleukin-1 beta secretion
GO:0050729 IMP positive regulation of inflammatory response
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051216 IEA cartilage development
GO:0060021 IMP palate development
GO:0060324 IMP face development
GO:0060340 IDA positive regulation of type I interferon-mediated signaling pathway
GO:0060760 IDA positive regulation of response to cytokine stimulus
GO:0060907 IMP positive regulation of macrophage cytokine production
GO:0070062 TAS extracellular vesicular exosome
GO:0071222 IEP cellular response to lipopolysaccharide
GO:0071277 IEP cellular response to calcium ion
GO:0071300 ISS cellular response to retinoic acid
GO:0071346 IEP cellular response to interferon-gamma
GO:0071425 IDA hematopoietic stem cell proliferation
GO:0071560 IEP cellular response to transforming growth factor beta stimulus
GO:0072201 IDA negative regulation of mesenchymal cell proliferation
GO:0090037 IMP positive regulation of protein kinase C signaling
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000063465 Wnt5a-001 protein_coding Mus_musculus 0 1953
ENSMUST00000134163 Wnt5a-003 processed_transcript Mus_musculus 0 1554
ENSMUST00000112272 Wnt5a-002 protein_coding Mus_musculus 0 1554
ENSDART00000122986 wnt5b-202 protein_coding Danio_rerio 0 676
ENSDART00000041852 wnt5b-201 protein_coding Danio_rerio 0 676
ENSDART00000074651 wnt5b-003 protein_coding Danio_rerio 0 676
ENSDART00000123877 wnt5a-202 protein_coding Danio_rerio 0 507
ENSDART00000023675 wnt5a-201 protein_coding Danio_rerio 0 507
ENSDART00000105133 wnt4a-001 protein_coding Danio_rerio 0.00000000000004 86

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