C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: wingless-type MMTV integration site family, member 5A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021994 Wnt5a 10090 + 14:28504750-28527447 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000063465 Wnt5a-001 28504750-28527447 protein_coding
  ENSMUST00000112272 Wnt5a-002 28511405-28525434 protein_coding
  ENSMUST00000134163 Wnt5a-003 28511390-28523517 processed_transcript
  ENSMUST00000134766 Wnt5a-004 28505900-28509121 processed_transcript
  ENSMUST00000146192 Wnt5a-006 28511451-28511907 processed_transcript
  ENSMUST00000151929 Wnt5a-005 28510618-28511925 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000063465ENSMUST00000112272ENSMUST00000134163
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000063465 10.198±7.91 15.907±3.14 16.289±0.69 1.989±1.30 4.630±1.95 3.330±0.73 0.851±0.41 2.131±0.54 0.220±0.16 2.970±0.49 0.352±0.11 20.179±9.88 0.319±0.20 0.335±0.17
ENSMUST00000112272 21.523±17.80 N/A 16.611±1.53 2.948±2.04 2.884±0.95 2.634±0.89 2.219±0.23 2.725±0.80 0.151±0.08 2.227±0.17 0.997±0.16 6.989±0.62 0.520±0.23 0.451±0.16
ENSMUST00000134163 3.292±0.03 N/A N/A 0.741±0.00 3.966±0.64 4.054±1.00 N/A N/A 0.245±0.17 N/A N/A 13.657±5.96 0.199±0.04 0.257±0.18

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00002X CIL_00002X_0002 CGP 14:27622442-28527447
CIL_00083K CIL_00083K_0002 VISTA 14:28201106-28802535
CIL_0007P0 CIL_0007P0_0002 UCNEbase 14:28252385-28776030
CIL_00002U CIL_00002U_0002 CGP 14:28504750-29721864

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0001667 IMP ameboidal cell migration
GO:0001736 IMP establishment of planar polarity
GO:0001756 IGI somitogenesis
GO:0001837 IEA epithelial to mesenchymal transition
GO:0001843 IGI neural tube closure
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0001947 IGI heart looping
GO:0002009 IMP morphogenesis of an epithelium
GO:0002053 IMP positive regulation of mesenchymal cell proliferation
GO:0002741 IEA positive regulation of cytokine secretion involved in immune response
GO:0003323 IMP type B pancreatic cell development
GO:0003344 IGI pericardium morphogenesis
GO:0003401 IMP axis elongation
GO:0003700 ISS sequence-specific DNA binding transcription factor activity
GO:0005102 IPI receptor binding
GO:0005109 IPI frizzled binding
GO:0005110 IDA frizzled-2 binding
GO:0005115 IEA receptor tyrosine kinase-like orphan receptor binding
GO:0005125 IDA cytokine activity
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IBA extracellular space
GO:0005788 TAS endoplasmic reticulum lumen
GO:0006468 IGI protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007223 IMP Wnt signaling pathway, calcium modulating pathway
GO:0007254 IDA JNK cascade
GO:0007257 IEA activation of JUN kinase activity
GO:0007267 TAS cell-cell signaling
GO:0007368 IMP determination of left/right symmetry
GO:0007411 IDA axon guidance
GO:0007442 IMP hindgut morphogenesis
GO:0007494 IMP midgut development
GO:0008284 IDA positive regulation of cell proliferation
GO:0008584 IMP male gonad development
GO:0008595 IDA anterior/posterior axis specification, embryo
GO:0009887 TAS organ morphogenesis
GO:0009952 IMP anterior/posterior pattern specification
GO:0009986 IDA cell surface
GO:0010033 IEA response to organic substance
GO:0010595 IEA positive regulation of endothelial cell migration
GO:0010800 IGI positive regulation of peptidyl-threonine phosphorylation
GO:0010820 IEA positive regulation of T cell chemotaxis
GO:0010976 IDA positive regulation of neuron projection development
GO:0016055 IGI Wnt signaling pathway
GO:0016477 IMP cell migration
GO:0019904 IPI protein domain specific binding
GO:0021891 IMP olfactory bulb interneuron development
GO:0021915 IGI neural tube development
GO:0030216 IEA keratinocyte differentiation
GO:0030324 IMP lung development
GO:0030326 IMP embryonic limb morphogenesis
GO:0030514 IMP negative regulation of BMP signaling pathway
GO:0030825 IEA positive regulation of cGMP metabolic process
GO:0031012 IDA extracellular matrix
GO:0032148 IEA activation of protein kinase B activity
GO:0032729 IMP positive regulation of interferon-gamma production
GO:0032755 IDA positive regulation of interleukin-6 production
GO:0033138 IGI positive regulation of peptidyl-serine phosphorylation
GO:0034613 IMP cellular protein localization
GO:0035108 IMP limb morphogenesis
GO:0036342 IGI post-anal tail morphogenesis
GO:0038031 IMP non-canonical Wnt signaling pathway via JNK cascade
GO:0040037 IMP negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042060 IEA wound healing
GO:0042472 IDA inner ear morphogenesis
GO:0042733 IMP embryonic digit morphogenesis
GO:0043032 IEA positive regulation of macrophage activation
GO:0043066 IEA negative regulation of apoptotic process
GO:0043507 IDA positive regulation of JUN kinase activity
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045080 IEA positive regulation of chemokine biosynthetic process
GO:0045165 IBA cell fate commitment
GO:0045599 IEA negative regulation of fat cell differentiation
GO:0045732 IEA positive regulation of protein catabolic process
GO:0045766 IEA positive regulation of angiogenesis
GO:0045778 IEA positive regulation of ossification
GO:0045836 IGI positive regulation of meiosis
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IMP positive regulation of JNK cascade
GO:0046546 IMP development of primary male sexual characteristics
GO:0048146 IEA positive regulation of fibroblast proliferation
GO:0048546 IMP digestive tract morphogenesis
GO:0048706 IEA embryonic skeletal system development
GO:0048806 IEA genitalia development
GO:0048812 IDA neuron projection morphogenesis
GO:0048843 IGI negative regulation of axon extension involved in axon guidance
GO:0048850 IMP hypophysis morphogenesis
GO:0050679 IMP positive regulation of epithelial cell proliferation
GO:0050680 IDA negative regulation of epithelial cell proliferation
GO:0050718 IDA positive regulation of interleukin-1 beta secretion
GO:0050729 IEA positive regulation of inflammatory response
GO:0050919 IGI negative chemotaxis
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051216 IEA cartilage development
GO:0051964 IDA negative regulation of synapse assembly
GO:0060021 IEA palate development
GO:0060026 IMP convergent extension
GO:0060029 IGI convergent extension involved in organogenesis
GO:0060065 IMP uterus development
GO:0060067 IMP cervix development
GO:0060068 IMP vagina development
GO:0060070 IGI canonical Wnt signaling pathway
GO:0060071 IGI Wnt signaling pathway, planar cell polarity pathway
GO:0060157 IMP urinary bladder development
GO:0060324 IEA face development
GO:0060340 IEA positive regulation of type I interferon-mediated signaling pathway
GO:0060599 IDA lateral sprouting involved in mammary gland duct morphogenesis
GO:0060606 IMP tube closure
GO:0060638 IMP mesenchymal-epithelial cell signaling
GO:0060686 IMP negative regulation of prostatic bud formation
GO:0060744 IDA mammary gland branching involved in thelarche
GO:0060750 IDA epithelial cell proliferation involved in mammary gland duct elongation
GO:0060760 IEA positive regulation of response to cytokine stimulus
GO:0060762 IDA regulation of branching involved in mammary gland duct morphogenesis
GO:0060907 IEA positive regulation of macrophage cytokine production
GO:0061036 IDA positive regulation of cartilage development
GO:0061347 IMP planar cell polarity pathway involved in outflow tract morphogenesis
GO:0061348 IMP planar cell polarity pathway involved in ventricular septum morphogenesis
GO:0061349 IMP planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:0061350 IMP planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:0061354 IMP planar cell polarity pathway involved in pericardium morphogenesis
GO:0070245 IMP positive regulation of thymocyte apoptotic process
GO:0071219 IDA cellular response to molecule of bacterial origin
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071277 IEA cellular response to calcium ion
GO:0071346 IEA cellular response to interferon-gamma
GO:0071425 IDA hematopoietic stem cell proliferation
GO:0071542 IGI dopaminergic neuron differentiation
GO:0071560 IEA cellular response to transforming growth factor beta stimulus
GO:0072201 IEA negative regulation of mesenchymal cell proliferation
GO:0090009 IGI primitive streak formation
GO:0090037 IEA positive regulation of protein kinase C signaling
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway
GO:0090103 IGI cochlea morphogenesis
GO:0090179 IMP planar cell polarity pathway involved in neural tube closure
GO:2000049 IDA positive regulation of cell-cell adhesion mediated by cadherin
GO:2000484 IDA positive regulation of interleukin-8 secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014495 wnt5a wingless-type MMTV integration site family, member 5a protein_coding Danio_rerio
ENSG00000114251 WNT5A wingless-type MMTV integration site family, member 5A protein_coding Homo_sapiens

Loading