C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase, cAMP-dependent, regulatory, type II, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000114302 PRKAR2A 9606 - 3:48744597-48847846 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265563 PRKAR2A-001 48746579-48847846 protein_coding
  ENST00000296446 PRKAR2A-003 48749648-48847828 protein_coding
  ENST00000419216 PRKAR2A-007 48790599-48847833 protein_coding
  ENST00000437821 PRKAR2A-005 48751258-48794013 protein_coding
  ENST00000438535 PRKAR2A-006 48751339-48765350 protein_coding
  ENST00000454963 PRKAR2A-002 48747515-48847804 protein_coding
  ENST00000457914 PRKAR2A-004 48744597-48752318 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265563ENST00000296446ENST00000437821ENST00000438535ENST00000454963
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265563 11.014±0.00 5.061±0.00 1.586±0.00 3.585±2.15 7.025±4.01 2.423±0.56 6.790±4.89 3.735±1.12 4.011±0.00 2.334±0.03 15.622±12.32 6.297±3.31 4.975±2.29 7.719±0.17
ENST00000296446 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.861±0.00 1.058±0.00 N/A N/A
ENST00000437821 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 46.692±0.00
ENST00000438535 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 60.615±0.00
ENST00000454963 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.151±0.00 8.982±0.00 24.615±7.67

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003FN CIL_0003FN_0002 CGP 3:48744597-48898993

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001932 IEA regulation of protein phosphorylation
GO:0004862 IDA cAMP-dependent protein kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005925 IDA focal adhesion
GO:0005952 IEA cAMP-dependent protein kinase complex
GO:0006112 TAS energy reserve metabolic process
GO:0006833 TAS water transport
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007596 TAS blood coagulation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0008603 IDA:IEA cAMP-dependent protein kinase regulator activity
GO:0016020 IDA membrane
GO:0016301 IEA kinase activity
GO:0016310 IEA phosphorylation
GO:0030552 IEA cAMP binding
GO:0031588 IDA AMP-activated protein kinase complex
GO:0031625 IDA ubiquitin protein ligase binding
GO:0034199 TAS activation of protein kinase A activity
GO:0034236 IPI protein kinase A catalytic subunit binding
GO:0035556 TAS intracellular signal transduction
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0045859 IEA regulation of protein kinase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050796 TAS regulation of insulin secretion
GO:0055085 TAS transmembrane transport
GO:0070062 IDA extracellular vesicular exosome
GO:0071377 TAS cellular response to glucagon stimulus
GO:2000480 IDA negative regulation of cAMP-dependent protein kinase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009477 prkar2ab protein kinase, cAMP-dependent, regulatory, type II, alpha, B protein_coding Danio_rerio
ENSMUSG00000032601 Prkar2a protein kinase, cAMP dependent regulatory, type II alpha protein_coding Mus_musculus

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