C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase-activated protein kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000114738 MAPKAPK3 9606 + 3:50611520-50649297 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000357955 MAPKAPK3-001 50617170-50649288 protein_coding
  ENST00000430409 MAPKAPK3-005 50617131-50647204 protein_coding
  ENST00000446044 MAPKAPK3-002 50611908-50649289 protein_coding
  ENST00000451680 MAPKAPK3-007 50646212-50648627 protein_coding
  ENST00000457064 MAPKAPK3-006 50617390-50640505 protein_coding
  ENST00000486712 MAPKAPK3-003 50611520-50613900 processed_transcript
  ENST00000497283 MAPKAPK3-004 50612328-50614117 processed_transcript
  ENST00000621469 MAPKAPK3-201 50617131-50649297 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000357955ENST00000430409ENST00000446044ENST00000451680ENST00000621469
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000357955 4.238±0.00 11.080±0.00 1.453±0.00 2.822±1.42 2.210±1.47 2.875±1.96 42.214±33.18 27.813±0.00 6.891±0.00 3.385±1.50 29.608±16.14 10.004±2.55 11.281±2.29 2.933±0.41
ENST00000430409 N/A N/A N/A 1.360±0.96 1.790±0.00 N/A 18.120±13.57 N/A N/A N/A N/A N/A N/A N/A
ENST00000446044 N/A N/A N/A N/A N/A 0.714±0.00 N/A N/A N/A N/A N/A 0.553±0.00 N/A 2.571±0.10
ENST00000451680 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.770±0.00 7.025±0.00 N/A
ENST00000621469 3.470±0.00 N/A N/A 1.123±0.00 7.465±0.00 1.823±0.00 16.049±10.23 1.361±0.00 1.664±0.00 7.737±0.00 18.444±0.00 5.362±2.89 N/A 1.630±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008D8 CIL_0008D8_0001 VISTA 3:50299047-50902727

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 TAS activation of MAPK activity
GO:0002224 ISS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004674 IEA:IDA protein serine/threonine kinase activity
GO:0004708 TAS MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 TAS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006950 TAS response to stress
GO:0007165 TAS signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0031965 IDA nuclear membrane
GO:0032496 ISS response to lipopolysaccharide
GO:0034097 IDA response to cytokine
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0044351 ISS macropinocytosis
GO:0045087 TAS innate immune response
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051403 TAS stress-activated MAPK cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000089016 mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 protein_coding Danio_rerio
ENSMUSG00000032577 Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 protein_coding Mus_musculus

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