C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: activin A receptor, type I
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115170 ACVR1 9606 - 2:157736444-157875862 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000263640 ACVR1-001 157736444-157875111 protein_coding
  ENST00000409283 ACVR1-003 157736449-157806996 protein_coding
  ENST00000410057 ACVR1-009 157737316-157838278 protein_coding
  ENST00000412025 ACVR1-007 157780406-157838327 protein_coding
  ENST00000413751 ACVR1-006 157799429-157875840 protein_coding
  ENST00000424669 ACVR1-004 157780454-157875862 protein_coding
  ENST00000434821 ACVR1-201 157736449-157875862 protein_coding
  ENST00000440523 ACVR1-005 157780408-157875626 protein_coding
  ENST00000487456 ACVR1-008 157778150-157790237 processed_transcript
  ENST00000539637 ACVR1-002 157780450-157875840 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000263640ENST00000409283ENST00000410057ENST00000412025ENST00000434821ENST00000487456
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000263640 N/A N/A N/A N/A N/A 0.152±0.00 0.520±0.00 N/A N/A N/A N/A N/A N/A
ENST00000409283 N/A N/A N/A N/A N/A N/A N/A 0.433±0.00 N/A N/A N/A N/A N/A
ENST00000410057 N/A N/A 0.690±0.00 N/A 1.586±0.00 N/A N/A 0.966±0.00 N/A 2.953±0.00 2.853±0.60 N/A N/A
ENST00000412025 N/A N/A 1.484±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000434821 7.002±0.00 7.482±0.00 3.088±0.00 4.627±0.00 4.667±4.16 3.242±2.92 6.489±4.57 3.645±0.00 7.087±0.00 3.824±2.40 11.769±0.29 6.710±2.48 4.961±2.41
ENST00000487456 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.537±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000752 CIL_000752_0001 CGP 2:157526767-157875862

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IMP G1/S transition of mitotic cell cycle
GO:0001569 IEA patterning of blood vessels
GO:0001655 IEA urogenital system development
GO:0001701 IEA in utero embryonic development
GO:0001702 IEA gastrulation with mouth forming second
GO:0001707 IEA mesoderm formation
GO:0001755 IEA neural crest cell migration
GO:0002526 IEA acute inflammatory response
GO:0003143 IMP embryonic heart tube morphogenesis
GO:0003183 IMP mitral valve morphogenesis
GO:0003289 IMP atrial septum primum morphogenesis
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004675 NAS:IEA transmembrane receptor protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005024 IEA transforming growth factor beta-activated receptor activity
GO:0005025 IEA transforming growth factor beta receptor activity, type I
GO:0005515 IPI protein binding
GO:0005524 IEA:IDA ATP binding
GO:0005887 IDA integral component of plasma membrane
GO:0006468 IDA:IEA protein phosphorylation
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007281 IEA germ cell development
GO:0007368 IEA determination of left/right symmetry
GO:0007369 IEA gastrulation
GO:0007498 IEA mesoderm development
GO:0007507 IEA heart development
GO:0009968 IMP negative regulation of signal transduction
GO:0010862 IDA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016020 IEA membrane
GO:0016361 IDA activin receptor activity, type I
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017046 NAS peptide hormone binding
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0019838 IEA growth factor binding
GO:0030278 IMP regulation of ossification
GO:0030501 IMP positive regulation of bone mineralization
GO:0030509 IDA BMP signaling pathway
GO:0032924 IDA activin receptor signaling pathway
GO:0032926 IMP negative regulation of activin receptor signaling pathway
GO:0042803 IDA protein homodimerization activity
GO:0045177 IEA apical part of cell
GO:0045669 IMP positive regulation of osteoblast differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IDA SMAD binding
GO:0046872 IEA metal ion binding
GO:0048179 IDA activin receptor complex
GO:0048185 IDA activin binding
GO:0048641 IEA regulation of skeletal muscle tissue development
GO:0050431 IDA transforming growth factor beta binding
GO:0051145 IEA smooth muscle cell differentiation
GO:0060037 IEA pharyngeal system development
GO:0060389 IDA pathway-restricted SMAD protein phosphorylation
GO:0060923 IMP cardiac muscle cell fate commitment
GO:0061445 IMP endocardial cushion cell fate commitment
GO:0071385 IEA cellular response to glucocorticoid stimulus
GO:2000017 IDA positive regulation of determination of dorsal identity
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014986 acvr1l activin A receptor, type I like protein_coding Danio_rerio
ENSMUSG00000026836 Acvr1 activin A receptor, type 1 protein_coding Mus_musculus

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