C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: activin A receptor, type 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026836 Acvr1 10090 - 2:58388644-58567157 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000056376 Acvr1-004 58447149-58567157 protein_coding
  ENSMUST00000090935 Acvr1-003 58446441-58566826 protein_coding
  ENSMUST00000112599 Acvr1-001 58446434-58516272 protein_coding
  ENSMUST00000112601 Acvr1-201 58446441-58566828 protein_coding
  ENSMUST00000126407 Acvr1-005 58477758-58538438 protein_coding
  ENSMUST00000145495 Acvr1-002 58388644-58516272 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000056376ENSMUST00000090935ENSMUST00000112599ENSMUST00000112601
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000056376 N/A 0.709±0.00 2.322±0.45 1.276±0.00 0.932±0.00 N/A N/A N/A 0.544±0.02 N/A 1.366±0.25 2.486±1.77 N/A 0.599±0.00
ENSMUST00000090935 N/A N/A N/A N/A N/A 1.052±0.00 N/A N/A 0.407±0.06 N/A N/A N/A N/A 0.125±0.00
ENSMUST00000112599 1.392±0.53 5.360±0.65 6.972±0.00 4.015±0.86 1.456±0.53 2.096±0.62 1.835±0.78 1.206±0.72 2.303±0.92 2.847±1.02 2.341±0.65 3.947±1.20 1.915±0.52 0.736±0.51
ENSMUST00000112601 1.981±0.58 2.537±0.57 2.340±0.26 3.954±1.46 1.647±0.48 1.114±0.50 1.121±0.46 1.098±0.26 0.857±0.16 1.626±0.48 2.257±1.09 3.168±0.82 2.180±1.17 0.371±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000752 CIL_000752_0002 CGP 2:58267453-58567157

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IEA G1/S transition of mitotic cell cycle
GO:0001569 IMP patterning of blood vessels
GO:0001655 IEA urogenital system development
GO:0001701 IMP in utero embryonic development
GO:0001702 IMP gastrulation with mouth forming second
GO:0001707 IMP mesoderm formation
GO:0001755 IMP neural crest cell migration
GO:0002526 IEP acute inflammatory response
GO:0003143 IEA embryonic heart tube morphogenesis
GO:0003183 IEA mitral valve morphogenesis
GO:0003289 IEA atrial septum primum morphogenesis
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0005025 IDA transforming growth factor beta receptor activity, type I
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005887 IDA integral component of plasma membrane
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007281 IMP germ cell development
GO:0007368 IMP determination of left/right symmetry
GO:0007369 IMP gastrulation
GO:0007498 IMP mesoderm development
GO:0007507 IMP heart development
GO:0009968 IEA negative regulation of signal transduction
GO:0010862 IEA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016361 IDA activin receptor activity, type I
GO:0018107 IEA peptidyl-threonine phosphorylation
GO:0019838 IDA growth factor binding
GO:0030278 IEA regulation of ossification
GO:0030501 IEA positive regulation of bone mineralization
GO:0030509 IEA BMP signaling pathway
GO:0032924 IDA activin receptor signaling pathway
GO:0032926 IEA negative regulation of activin receptor signaling pathway
GO:0042803 IEA protein homodimerization activity
GO:0045177 IDA apical part of cell
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IEA SMAD binding
GO:0046872 IEA metal ion binding
GO:0048179 IEA activin receptor complex
GO:0048185 IPI activin binding
GO:0048641 IEA regulation of skeletal muscle tissue development
GO:0050431 IDA transforming growth factor beta binding
GO:0051145 IMP smooth muscle cell differentiation
GO:0060037 IMP pharyngeal system development
GO:0060389 IEA pathway-restricted SMAD protein phosphorylation
GO:0060923 IEA cardiac muscle cell fate commitment
GO:0061445 IEA endocardial cushion cell fate commitment
GO:0071385 IEA cellular response to glucocorticoid stimulus
GO:2000017 IEA positive regulation of determination of dorsal identity
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014986 acvr1l activin A receptor, type I like protein_coding Danio_rerio
ENSG00000115170 ACVR1 activin A receptor, type I protein_coding Homo_sapiens

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