C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: activin A receptor, type I
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000263640 ACVR1-001 ENSG00000115170 9606 - 2:157736444-157875111 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; HeartKidneyENST00000263640
Transcript ID Heart Kidney
ENST00000263640 0.152±0.00 0.520±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000752 CIL_000752_0001 CGP 2:157526767-157875862

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000082 IMP G1/S transition of mitotic cell cycle
GO:0001569 IEA patterning of blood vessels
GO:0001655 IEA urogenital system development
GO:0001701 IEA in utero embryonic development
GO:0001702 IEA gastrulation with mouth forming second
GO:0001707 IEA mesoderm formation
GO:0001755 IEA neural crest cell migration
GO:0002526 IEA acute inflammatory response
GO:0003143 IMP embryonic heart tube morphogenesis
GO:0003183 IMP mitral valve morphogenesis
GO:0003289 IMP atrial septum primum morphogenesis
GO:0004672 IDA:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004675 NAS:IEA transmembrane receptor protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005024 IEA transforming growth factor beta-activated receptor activity
GO:0005025 IEA transforming growth factor beta receptor activity, type I
GO:0005515 IPI protein binding
GO:0005524 IEA:IDA ATP binding
GO:0005887 IDA integral component of plasma membrane
GO:0006468 IDA:IEA protein phosphorylation
GO:0007179 IDA transforming growth factor beta receptor signaling pathway
GO:0007281 IEA germ cell development
GO:0007368 IEA determination of left/right symmetry
GO:0007369 IEA gastrulation
GO:0007498 IEA mesoderm development
GO:0007507 IEA heart development
GO:0009968 IMP negative regulation of signal transduction
GO:0010862 IDA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016020 IEA membrane
GO:0016361 IDA activin receptor activity, type I
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017046 NAS peptide hormone binding
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0019838 IEA growth factor binding
GO:0030278 IMP regulation of ossification
GO:0030501 IMP positive regulation of bone mineralization
GO:0030509 IDA BMP signaling pathway
GO:0032924 IDA activin receptor signaling pathway
GO:0032926 IMP negative regulation of activin receptor signaling pathway
GO:0042803 IDA protein homodimerization activity
GO:0045177 IEA apical part of cell
GO:0045669 IMP positive regulation of osteoblast differentiation
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IDA SMAD binding
GO:0046872 IEA metal ion binding
GO:0048179 IDA activin receptor complex
GO:0048185 IDA activin binding
GO:0048641 IEA regulation of skeletal muscle tissue development
GO:0050431 IDA transforming growth factor beta binding
GO:0051145 IEA smooth muscle cell differentiation
GO:0060037 IEA pharyngeal system development
GO:0060389 IDA pathway-restricted SMAD protein phosphorylation
GO:0060923 IMP cardiac muscle cell fate commitment
GO:0061445 IMP endocardial cushion cell fate commitment
GO:0071385 IEA cellular response to glucocorticoid stimulus
GO:2000017 IDA positive regulation of determination of dorsal identity
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000112599 Acvr1-001 protein_coding Mus_musculus 0 3192
ENSMUST00000112601 Acvr1-201 protein_coding Mus_musculus 0 3186
ENSMUST00000090935 Acvr1-003 protein_coding Mus_musculus 0 3186
ENSMUST00000056376 Acvr1-004 protein_coding Mus_musculus 0 2311
ENSMUST00000145495 Acvr1-002 processed_transcript Mus_musculus 0 1652
ENSMUST00000126407 Acvr1-005 protein_coding Mus_musculus 0 534

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