C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115211 EIF2B4 9606 - 2:27364352-27370486 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000347454 EIF2B4-001 27364352-27370486 protein_coding
  ENST00000405940 EIF2B4-004 27364377-27370315 nonsense_mediated_decay
  ENST00000417567 EIF2B4-008 27366763-27368727 nonsense_mediated_decay
  ENST00000418146 EIF2B4-005 27368413-27370329 nonsense_mediated_decay
  ENST00000445933 EIF2B4-007 27364381-27370334 protein_coding
  ENST00000451130 EIF2B4-011 27364399-27370013 protein_coding
  ENST00000462749 EIF2B4-006 27368670-27370326 retained_intron
  ENST00000475582 EIF2B4-003 27365558-27370323 retained_intron
  ENST00000478311 EIF2B4-009 27364358-27365082 retained_intron
  ENST00000493344 EIF2B4-002 27364399-27370326 protein_coding
  ENST00000616081 EIF2B4-201 27364352-27370457 protein_coding
  ENST00000622434 EIF2B4-202 27364363-27370300 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000347454ENST00000405940ENST00000445933ENST00000475582ENST00000478311ENST00000493344ENST00000622434
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000347454 9.386±0.00 N/A 12.330±0.00 N/A 14.946±0.00 N/A N/A N/A N/A 10.889±0.00 11.432±0.00 12.131±3.81 24.076±3.86
ENST00000405940 N/A N/A N/A N/A N/A 4.158±2.82 N/A N/A N/A 10.140±0.00 N/A N/A N/A
ENST00000445933 10.096±0.00 27.901±0.00 2.546±0.00 9.824±7.02 19.651±0.00 5.580±4.48 N/A 5.351±2.95 10.226±0.00 11.200±9.66 15.188±5.37 10.593±3.28 24.327±4.33
ENST00000475582 N/A N/A N/A 0.870±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000478311 N/A N/A N/A N/A N/A N/A 7.853±0.00 N/A N/A 5.723±0.00 N/A N/A N/A
ENST00000493344 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 18.565±0.00
ENST00000622434 N/A N/A N/A N/A N/A N/A 26.947±0.00 4.403±0.00 8.146±0.00 N/A N/A 10.329±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001DH CIL_0001DH_0001 CGP 2:27325849-27370486
CIL_000133 CIL_000133_0001 CGP 2:27364352-27377533

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001541 IMP ovarian follicle development
GO:0003743 IDA translation initiation factor activity
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005851 IDA eukaryotic translation initiation factor 2B complex
GO:0006412 TAS translation
GO:0006413 IDA translational initiation
GO:0006417 NAS regulation of translation
GO:0006446 IBA regulation of translational initiation
GO:0009408 ISS response to heat
GO:0009749 ISS response to glucose
GO:0010467 TAS gene expression
GO:0014003 IMP oligodendrocyte development
GO:0031369 ISS translation initiation factor binding
GO:0032057 ISS negative regulation of translational initiation in response to stress
GO:0042552 IMP myelination
GO:0043434 ISS response to peptide hormone
GO:0043547 IDA positive regulation of GTPase activity
GO:0044237 IEA cellular metabolic process
GO:0044267 TAS cellular protein metabolic process
GO:0045947 IBA negative regulation of translational initiation
GO:0051716 IDA cellular response to stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014004 eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta protein_coding Danio_rerio
ENSMUSG00000029145 Eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta protein_coding Mus_musculus

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