C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115233 PSMD14 9606 + 2:161308038-161411717 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000409682 PSMD14-001 161308038-161411717 protein_coding
  ENST00000437630 PSMD14-002 161308600-161370119 protein_coding
  ENST00000477232 PSMD14-005 161381360-161411715 retained_intron
  ENST00000478123 PSMD14-003 161308461-161319022 retained_intron
  ENST00000492908 PSMD14-006 161407528-161411715 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000409682ENST00000477232
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000409682 9.286±0.00 9.936±0.00 2.209±0.00 11.821±4.60 5.971±2.79 10.363±4.67 10.049±4.50 5.547±0.45 13.974±6.99 3.742±0.83 7.526±3.02 14.509±3.88 41.186±32.04 34.018±0.00
ENST00000477232 N/A N/A 0.265±0.00 N/A 0.972±0.00 0.806±0.00 N/A N/A 0.569±0.00 0.686±0.00 N/A 1.107±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008JH CIL_0008JH_0001 VISTA 2:160938384-161538940
CIL_0005L0 CIL_0005L0_0001 CGP 2:161136908-161411717
CIL_0007OV CIL_0007OV_0001 UCNEbase 2:161238541-161382542
CIL_0005L1 CIL_0005L1_0001 CGP 2:161308038-161425870

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 IDA proteasome complex
GO:0000724 IMP double-strand break repair via homologous recombination
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004221 TAS ubiquitin thiolesterase activity
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006303 IMP double-strand break repair via nonhomologous end joining
GO:0006511 TAS ubiquitin-dependent protein catabolic process
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008237 TAS metallopeptidase activity
GO:0008541 IMP proteasome regulatory particle, lid subcomplex
GO:0010467 TAS gene expression
GO:0010950 IMP positive regulation of endopeptidase activity
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0022624 ISS proteasome accessory complex
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0046872 IEA metal ion binding
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0061133 IMP endopeptidase activator activity
GO:0061136 IMP regulation of proteasomal protein catabolic process
GO:0070062 IDA extracellular vesicular exosome
GO:0070536 TAS protein K63-linked deubiquitination
GO:0070628 IDA proteasome binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000063100 psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 protein_coding Danio_rerio
ENSMUSG00000026914 Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 protein_coding Mus_musculus

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