C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: four and a half LIM domains 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115641 FHL2 9606 - 2:105357712-105438513 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000322142 FHL2-004 105360828-105399061 protein_coding
  ENST00000344213 FHL2-002 105360812-105399224 protein_coding
  ENST00000358129 FHL2-201 105360828-105399224 protein_coding
  ENST00000393352 FHL2-009 105360826-105438503 protein_coding
  ENST00000393353 FHL2-003 105360826-105399051 protein_coding
  ENST00000408995 FHL2-005 105360861-105399050 protein_coding
  ENST00000409177 FHL2-006 105357712-105399667 protein_coding
  ENST00000409807 FHL2-001 105360857-105396957 protein_coding
  ENST00000447958 FHL2-007 105386458-105396785 protein_coding
  ENST00000452732 FHL2-008 105363284-105396697 nonsense_mediated_decay
  ENST00000530340 FHL2-010 105360826-105399224 nonsense_mediated_decay
  ENST00000607522 FHL2-011 105385897-105438513 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000322142ENST00000344213ENST00000393352ENST00000393353ENST00000408995ENST00000409177ENST00000409807ENST00000530340ENST00000607522
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000322142 10.379±0.00 19.732±0.00 N/A N/A 2.168±0.00 4.654±0.00 77.772±0.00 4.269±0.00 1.859±1.38 2.009±0.00 2.242±0.00 8.617±0.05 15.731±2.37 17.568±13.86
ENST00000344213 N/A N/A N/A 2.399±0.00 N/A N/A N/A N/A N/A N/A N/A 75.629±36.54 13.292±0.91 5.298±0.00
ENST00000393352 N/A N/A N/A 2.598±0.00 6.533±0.00 N/A 284.110±179.99 N/A N/A N/A N/A 18.539±0.00 N/A N/A
ENST00000393353 21.462±0.00 7.847±0.00 N/A 4.425±0.00 12.557±0.00 36.582±0.00 N/A 4.515±0.00 2.142±1.40 10.885±0.00 5.747±0.00 154.504±56.48 35.902±8.85 86.296±0.00
ENST00000408995 N/A N/A 2.648±0.00 1.115±0.00 9.231±0.00 5.135±0.00 N/A 1.526±0.00 N/A 4.523±0.00 7.967±5.35 83.876±53.45 27.526±7.39 9.585±0.00
ENST00000409177 N/A 1.932±0.00 N/A N/A N/A N/A N/A N/A 0.375±0.00 0.424±0.00 N/A N/A N/A 1.297±0.00
ENST00000409807 N/A N/A N/A N/A N/A N/A N/A N/A 1.614±0.00 N/A N/A N/A N/A N/A
ENST00000530340 N/A N/A N/A 1.403±0.00 N/A N/A N/A 2.083±0.00 0.382±0.00 N/A N/A N/A N/A N/A
ENST00000607522 N/A N/A 1.766±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00096O CIL_00096O_0001 VISTA 2:104780753-105381700
CIL_00010E CIL_00010E_0001 CGP 2:105337359-105438513
CIL_00010G CIL_00010G_0001 CGP 2:105357712-105894274

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001649 IEA osteoblast differentiation
GO:0003713 NAS transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005925 IDA focal adhesion
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0008134 IPI transcription factor binding
GO:0008270 IEA zinc ion binding
GO:0009725 IMP response to hormone
GO:0015629 IDA actin cytoskeleton
GO:0030018 IEA Z disc
GO:0030521 NAS androgen receptor signaling pathway
GO:0031430 IEA M band
GO:0042802 IPI identical protein binding
GO:0043066 IDA negative regulation of apoptotic process
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 NAS positive regulation of transcription, DNA-templated
GO:0050681 NAS androgen receptor binding
GO:0055014 IEA atrial cardiac muscle cell development
GO:0055015 IEA ventricular cardiac muscle cell development
GO:0060347 IEA heart trabecula formation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003991 fhl2b four and a half LIM domains 2b protein_coding Danio_rerio
ENSDARG00000042018 fhl2a four and a half LIM domains 2a protein_coding Danio_rerio
ENSMUSG00000008136 Fhl2 four and a half LIM domains 2 protein_coding Mus_musculus

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