C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pleckstrin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115956 PLEK 9606 + 2:68365173-68397453 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000234313 PLEK-001 68365173-68397453 protein_coding
  ENST00000474788 PLEK-002 68387942-68395717 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000234313ENST00000474788
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000234313 2.994±0.00 12.547±0.00 0.600±0.00 1.347±0.78 4.749±0.51 0.952±0.56 1.112±0.92 2.131±0.40 0.993±0.61 10.976±1.87 0.638±0.00 1.957±0.82 11.856±0.55 1.449±0.81
ENST00000474788 N/A N/A N/A N/A 1.490±0.00 N/A N/A 2.981±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008I2 CIL_0008I2_0001 VISTA 2:67892841-68494859

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002244 IEP hematopoietic progenitor cell differentiation
GO:0002576 IEP platelet degranulation
GO:0005080 IDA protein kinase C binding
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006904 ISS vesicle docking involved in exocytosis
GO:0007229 IDA integrin-mediated signaling pathway
GO:0007596 TAS blood coagulation
GO:0010572 ISS positive regulation of platelet activation
GO:0010920 IDA negative regulation of inositol phosphate biosynthetic process
GO:0010925 IDA positive regulation of inositol-polyphosphate 5-phosphatase activity
GO:0016020 IDA membrane
GO:0030030 IDA cell projection organization
GO:0030168 TAS platelet activation
GO:0030836 IDA positive regulation of actin filament depolymerization
GO:0030845 IDA phospholipase C-inhibiting G-protein coupled receptor signaling pathway
GO:0030866 IDA cortical actin cytoskeleton organization
GO:0031529 IDA ruffle organization
GO:0031532 IDA actin cytoskeleton reorganization
GO:0032233 IDA positive regulation of actin filament bundle assembly
GO:0032587 IDA ruffle membrane
GO:0033625 ISS positive regulation of integrin activation
GO:0035556 IEA intracellular signal transduction
GO:0042803 IDA protein homodimerization activity
GO:0043325 IDA phosphatidylinositol-3,4-bisphosphate binding
GO:0045744 IDA negative regulation of G-protein coupled receptor protein signaling pathway
GO:0046488 IDA phosphatidylinositol metabolic process
GO:0050849 NAS negative regulation of calcium-mediated signaling
GO:0060305 IDA regulation of cell diameter
GO:0070493 IDA thrombin receptor signaling pathway
GO:0070527 ISS platelet aggregation
GO:0070528 ISS protein kinase C signaling
GO:0070560 ISS protein secretion by platelet

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017298 plek pleckstrin protein_coding Danio_rerio
ENSMUSG00000020120 Plek pleckstrin protein_coding Mus_musculus

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