C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pleckstrin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020120 Plek 10090 - 11:16971206-17052381 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000020321 Plek-002 16971464-17052381 protein_coding
  ENSMUST00000102881 Plek-001 16971206-17008702 protein_coding
  ENSMUST00000156101 Plek-003 16994820-17002999 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000020321ENSMUST00000102881
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000020321 1.037±0.34 1.089±0.00 0.963±0.00 N/A 0.901±0.00 0.794±0.22 0.329±0.05 0.525±0.55 N/A 0.207±0.11 0.390±0.00 0.524±0.00 0.185±0.09
ENSMUST00000102881 1.508±0.50 1.514±0.07 0.815±0.00 4.188±0.81 0.825±0.24 0.679±0.30 0.666±0.07 5.850±5.07 5.673±0.78 0.466±0.43 2.029±0.52 1.775±0.85 0.153±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008I2 CIL_0008I2_0002 VISTA 11:16884831-17492556
CIL_0003RT CIL_0003RT_0002 CGP 11:16971206-17079371

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002244 IEA hematopoietic progenitor cell differentiation
GO:0002576 IEA platelet degranulation
GO:0005080 IEA protein kinase C binding
GO:0005515 IEA protein binding
GO:0005737 IEA cytoplasm
GO:0006904 IMP vesicle docking involved in exocytosis
GO:0007229 IEA integrin-mediated signaling pathway
GO:0010572 IMP positive regulation of platelet activation
GO:0010920 IEA negative regulation of inositol phosphate biosynthetic process
GO:0010925 IEA positive regulation of inositol-polyphosphate 5-phosphatase activity
GO:0016020 IEA membrane
GO:0030030 IEA cell projection organization
GO:0030836 IMP positive regulation of actin filament depolymerization
GO:0030845 IEA phospholipase C-inhibiting G-protein coupled receptor signaling pathway
GO:0030866 IEA cortical actin cytoskeleton organization
GO:0031529 IEA ruffle organization
GO:0031532 IEA actin cytoskeleton reorganization
GO:0032233 IEA positive regulation of actin filament bundle assembly
GO:0032587 IEA ruffle membrane
GO:0033625 IMP positive regulation of integrin activation
GO:0035556 IEA intracellular signal transduction
GO:0042803 IEA protein homodimerization activity
GO:0043325 IEA phosphatidylinositol-3,4-bisphosphate binding
GO:0045744 IEA negative regulation of G-protein coupled receptor protein signaling pathway
GO:0046488 IEA phosphatidylinositol metabolic process
GO:0060305 IEA regulation of cell diameter
GO:0070493 IMP thrombin receptor signaling pathway
GO:0070527 IMP platelet aggregation
GO:0070528 IMP protein kinase C signaling
GO:0070560 IMP protein secretion by platelet

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017298 plek pleckstrin protein_coding Danio_rerio
ENSG00000115956 PLEK pleckstrin protein_coding Homo_sapiens

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