C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: endothelial PAS domain protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000116016 EPAS1 9606 + 2:46293667-46386703 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000263734 EPAS1-001 46297402-46386703 protein_coding
  ENST00000449347 EPAS1-007 46296608-46361090 protein_coding
  ENST00000460015 EPAS1-002 46293667-46346998 processed_transcript
  ENST00000463191 EPAS1-005 46356115-46361051 retained_intron
  ENST00000465318 EPAS1-006 46381177-46382504 retained_intron
  ENST00000466465 EPAS1-010 46379700-46386696 retained_intron
  ENST00000467888 EPAS1-004 46297764-46347537 processed_transcript
  ENST00000468530 EPAS1-009 46381635-46384550 processed_transcript
  ENST00000475822 EPAS1-003 46335690-46356293 processed_transcript
  ENST00000483692 EPAS1-008 46375636-46378702 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000263734
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000263734 210.705±0.00 80.076±0.00 16.309±0.00 7.960±2.87 48.156±41.36 44.041±36.37 26.841±15.16 21.025±6.94 15.809±5.18 578.387±465.76 17.301±0.00 15.663±14.94 191.153±41.23 10.771±4.69

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003T8 CIL_0003T8_0002 CGP 2:45651345-46386703
CIL_0001NQ CIL_0001NQ_0001 CGP 2:46293667-46484425

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001525 IEA angiogenesis
GO:0001666 IDA response to hypoxia
GO:0001892 IEA embryonic placenta development
GO:0001974 IEA blood vessel remodeling
GO:0002027 IEA regulation of heart rate
GO:0003677 IGI DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0004871 IEA signal transducer activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006979 IEA response to oxidative stress
GO:0007005 IEA mitochondrion organization
GO:0007165 IEA signal transduction
GO:0007601 IEA visual perception
GO:0008134 IPI transcription factor binding
GO:0030097 IEA hemopoiesis
GO:0030154 IEA cell differentiation
GO:0030218 IEA erythrocyte differentiation
GO:0030324 IEA lung development
GO:0035035 IPI histone acetyltransferase binding
GO:0042415 IEA norepinephrine metabolic process
GO:0043129 IEA surfactant homeostasis
GO:0043565 IDA sequence-specific DNA binding
GO:0043619 IEA regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IPI protein heterodimerization activity
GO:0046983 IEA protein dimerization activity
GO:0048469 IEA cell maturation
GO:0048625 ISS myoblast fate commitment
GO:0055072 IEA iron ion homeostasis
GO:0061418 TAS regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 IDA cellular response to hypoxia

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008697 epas1a endothelial PAS domain protein 1a protein_coding Danio_rerio
ENSDARG00000057671 epas1b endothelial PAS domain protein 1b protein_coding Danio_rerio
ENSMUSG00000024140 Epas1 endothelial PAS domain protein 1 protein_coding Mus_musculus

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