C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000116711 PLA2G4A 9606 + 1:186828953-186988981 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000367466 PLA2G4A-001 186828953-186988981 protein_coding
  ENST00000466600 PLA2G4A-002 186854286-186939230 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000367466ENST00000466600
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000367466 0.706±0.00 3.835±0.00 0.309±0.00 0.872±0.52 5.170±4.79 2.506±2.24 0.550±0.09 4.749±0.00 0.838±0.52 2.935±1.91 0.589±0.00 1.961±0.09 1.295±0.29 2.757±1.84
ENST00000466600 N/A N/A 1.391±0.00 N/A N/A N/A N/A 0.162±0.00 N/A N/A N/A N/A 0.408±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001BP CIL_0001BP_0003 CGP 1:186671791-186988981

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004620 IEA phospholipase activity
GO:0004622 IEA lysophospholipase activity
GO:0004623 NAS phospholipase A2 activity
GO:0005509 IDA calcium ion binding
GO:0005515 IEA protein binding
GO:0005544 IDA calcium-dependent phospholipid binding
GO:0005737 IDA cytoplasm
GO:0005743 TAS mitochondrial inner membrane
GO:0005783 IEA endoplasmic reticulum
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005794 IEA Golgi apparatus
GO:0005829 NAS cytosol
GO:0006644 TAS phospholipid metabolic process
GO:0006654 TAS phosphatidic acid biosynthetic process
GO:0006663 NAS platelet activating factor biosynthetic process
GO:0006690 NAS icosanoid metabolic process
GO:0007596 TAS blood coagulation
GO:0008152 IEA metabolic process
GO:0009395 IEA phospholipid catabolic process
GO:0019369 TAS arachidonic acid metabolic process
GO:0030168 TAS platelet activation
GO:0031410 IEA cytoplasmic vesicle
GO:0035965 TAS cardiolipin acyl-chain remodeling
GO:0036148 TAS phosphatidylglycerol acyl-chain remodeling
GO:0036149 TAS phosphatidylinositol acyl-chain remodeling
GO:0036150 TAS phosphatidylserine acyl-chain remodeling
GO:0036151 TAS phosphatidylcholine acyl-chain remodeling
GO:0036152 TAS phosphatidylethanolamine acyl-chain remodeling
GO:0042127 IEA regulation of cell proliferation
GO:0044281 TAS small molecule metabolic process
GO:0046456 IEA icosanoid biosynthetic process
GO:0046474 TAS glycerophospholipid biosynthetic process
GO:0047498 EXP calcium-dependent phospholipase A2 activity
GO:0050482 IEA arachidonic acid secretion
GO:0071236 IEA cellular response to antibiotic

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017141 pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) protein_coding Danio_rerio
ENSDARG00000024546 cpla2 cytosolic phospholipase a2 protein_coding Danio_rerio
ENSMUSG00000056220 Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) protein_coding Mus_musculus

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