Institute of Cardiovascular Regeneration Webtool Repository

C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info
Description:	MPL proto-oncogene, thrombopoietin receptor
Gene Accession	Gene Name	Tax ID	Strand	Position	Gene Biotype
ENSG00000117400	MPL	9606	+	1:43337807-43352772	protein_coding
	Transcript Accession		Transcript Name	Position	Transcript Biotype
	ENST00000372470		MPL-001	43337807-43352772	protein_coding
	ENST00000413998		MPL-002	43337849-43349537	protein_coding
	ENST00000612993		MPL-201	43337849-43349537	protein_coding

Expression Patterns

Transcript ID	Adipose	Adrenal	Bladder	Brain	Breast	Colon	Heart	Kidney	Liver	Lung	Ovary	Placenta	Testis
ENST00000372470	0.134±0.00	0.182±0.00	N/A	N/A	0.474±0.00	0.181±0.00	0.134±0.00	0.051±0.00	N/A	0.156±0.00	0.175±0.00	0.094±0.02	0.404±0.00
ENST00000413998	N/A	N/A	0.117±0.00	0.028±0.00	N/A	0.062±0.00	N/A	N/A	0.025±0.00	0.070±0.00	N/A	0.099±0.00	0.219±0.00

Conserved Regions
Region ID	Sub-Region	Region Type	Position
CIL_0008N2	CIL_0008N2_0001	VISTA	1:42758169-43359178

Gene Ontology
GO ID	Evidence Type	GO Description
GO:0004888	TAS	transmembrane signaling receptor activity
GO:0004896	IEA	cytokine receptor activity
GO:0005515	IEA	protein binding
GO:0005886	IDA	plasma membrane
GO:0005887	TAS	integral component of plasma membrane
GO:0007166	TAS	cell surface receptor signaling pathway
GO:0007596	TAS	blood coagulation
GO:0008283	TAS	cell proliferation
GO:0016020	IEA	membrane
GO:0019221	IEA	cytokine-mediated signaling pathway
GO:0030168	TAS	platelet activation
GO:0032642	IEA	regulation of chemokine production
GO:0048872	IEA	homeostasis of number of cells

Homologs
ENSEMBL Accession	Gene Name	Description	Biotype	Species
ENSDARG00000039222	mpl	myeloproliferative leukemia virus oncogene	protein_coding	Danio_rerio
ENSMUSG00000006389	Mpl	myeloproliferative leukemia virus oncogene	protein_coding	Mus_musculus

Loading