C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: calsequestrin 2 (cardiac muscle)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000118729 CASQ2 9606 - 1:115700007-115768781 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261448 CASQ2-001 115700007-115768781 protein_coding
  ENST00000488931 CASQ2-002 115727025-115732927 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261448
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261448 3.298±0.00 15.090±0.00 0.198±0.00 0.800±0.20 6.777±1.76 14.471±11.28 108.314±29.25 1.037±0.00 10.761±10.66 2.838±1.70 17.959±3.41 1.417±1.10 1.652±0.72 5.838±4.88

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008HI CIL_0008HI_0001 VISTA 1:115492363-116093752

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002027 IMP regulation of heart rate
GO:0005509 IDA:IEA calcium ion binding
GO:0005513 TAS detection of calcium ion
GO:0005515 IPI protein binding
GO:0005622 IMP intracellular
GO:0005737 IDA cytoplasm
GO:0005891 ISS voltage-gated calcium channel complex
GO:0006941 TAS striated muscle contraction
GO:0010649 IMP regulation of cell communication by electrical coupling
GO:0010880 ISS regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 IMP regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014701 TAS junctional sarcoplasmic reticulum membrane
GO:0016529 ISS sarcoplasmic reticulum
GO:0030018 ISS Z disc
GO:0030314 IEA junctional membrane complex
GO:0033017 TAS sarcoplasmic reticulum membrane
GO:0033018 IC sarcoplasmic reticulum lumen
GO:0034220 TAS ion transmembrane transport
GO:0034704 TAS calcium channel complex
GO:0042803 ISS protein homodimerization activity
GO:0043267 ISS negative regulation of potassium ion transport
GO:0045214 IEA sarcomere organization
GO:0048306 IDA calcium-dependent protein binding
GO:0051208 IDA sequestering of calcium ion
GO:0051258 IDA protein polymerization
GO:0055085 TAS transmembrane transport
GO:0060048 IMP cardiac muscle contraction
GO:0060306 ISS regulation of membrane repolarization
GO:0060315 ISS negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0071313 IMP cellular response to caffeine
GO:0086029 NAS Purkinje myocyte to ventricular cardiac muscle cell signaling
GO:1901017 ISS negative regulation of potassium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008982 casq2 calsequestrin 2 protein_coding Danio_rerio
ENSMUSG00000027861 Casq2 calsequestrin 2 protein_coding Mus_musculus

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