C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tumor necrosis factor (ligand) superfamily, member 11
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000120659 TNFSF11 9606 + 13:42562736-42608013 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000239849 TNFSF11-201 42574304-42606918 protein_coding
  ENST00000358545 TNFSF11-002 42562736-42607174 protein_coding
  ENST00000398795 TNFSF11-001 42574153-42608012 protein_coding
  ENST00000405262 TNFSF11-202 42566617-42608013 protein_coding
  ENST00000544862 TNFSF11-203 42574224-42606918 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000239849ENST00000358545ENST00000398795ENST00000544862
Transcript ID Adipose Adrenal Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000239849 N/A N/A N/A N/A N/A N/A N/A N/A 0.743±0.60 N/A N/A
ENST00000358545 0.026±0.00 N/A 0.012±0.00 N/A 0.015±0.00 N/A N/A N/A N/A N/A 0.938±0.60
ENST00000398795 0.029±0.00 4.242±0.00 0.464±0.44 0.126±0.00 N/A 0.224±0.21 0.197±0.00 0.043±0.00 0.164±0.15 N/A N/A
ENST00000544862 N/A N/A 0.028±0.00 0.225±0.00 0.031±0.00 N/A 0.163±0.00 N/A N/A 0.048±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007HB CIL_0007HB_0002 CGP 13:42272153-42608013
CIL_00086P CIL_00086P_0001 VISTA 13:42293235-42895461

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001503 IEA ossification
GO:0002158 IEA osteoclast proliferation
GO:0002548 IDA monocyte chemotaxis
GO:0005125 IDA cytokine activity
GO:0005164 NAS:IEA tumor necrosis factor receptor binding
GO:0005515 IEA protein binding
GO:0005576 NAS extracellular region
GO:0005615 IEA extracellular space
GO:0005622 IEA intracellular
GO:0005737 IEA cytoplasm
GO:0005887 NAS integral component of plasma membrane
GO:0006955 NAS:IEA immune response
GO:0007257 IEA activation of JUN kinase activity
GO:0009887 IEA organ morphogenesis
GO:0016020 IEA membrane
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0030316 ISS osteoclast differentiation
GO:0032813 IC tumor necrosis factor receptor superfamily binding
GO:0033209 ISS tumor necrosis factor-mediated signaling pathway
GO:0033598 IEA mammary gland epithelial cell proliferation
GO:0034112 IDA positive regulation of homotypic cell-cell adhesion
GO:0042327 IEA positive regulation of phosphorylation
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0045453 IEA bone resorption
GO:0045670 IEA regulation of osteoclast differentiation
GO:0045672 IDA positive regulation of osteoclast differentiation
GO:0045780 IDA positive regulation of bone resorption
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IEA positive regulation of JNK cascade
GO:0050870 IDA positive regulation of T cell activation
GO:0051091 ISS positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051260 IEA protein homooligomerization
GO:0051466 ISS positive regulation of corticotropin-releasing hormone secretion
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0055074 IEA calcium ion homeostasis
GO:0060749 IEA mammary gland alveolus development
GO:0070371 IEA ERK1 and ERK2 cascade
GO:0071812 ISS positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847 IDA TNFSF11-mediated signaling pathway
GO:0071848 IDA positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
GO:1902533 IDA positive regulation of intracellular signal transduction
GO:2001206 IEA positive regulation of osteoclast development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000068141 tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 protein_coding Danio_rerio
ENSMUSG00000022015 Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 protein_coding Mus_musculus

Loading