C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: tumor necrosis factor (ligand) superfamily, member 11
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000358545 TNFSF11-002 ENSG00000120659 9606 + 13:42562736-42607174 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBreastHeartTestisENST00000358545
Transcript ID Adipose Breast Heart Testis
ENST00000358545 0.026±0.00 0.012±0.00 0.015±0.00 0.938±0.60

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007HB CIL_0007HB_0002 CGP 13:42272153-42608013
CIL_00086P CIL_00086P_0001 VISTA 13:42293235-42895461

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002548 IDA monocyte chemotaxis
GO:0005125 IDA cytokine activity
GO:0005164 NAS:IEA tumor necrosis factor receptor binding
GO:0005515 IEA protein binding
GO:0005576 NAS extracellular region
GO:0005615 IEA extracellular space
GO:0005737 IEA cytoplasm
GO:0005887 NAS integral component of plasma membrane
GO:0006955 NAS:IEA immune response
GO:0016020 IEA membrane
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0030316 ISS osteoclast differentiation
GO:0032813 IC tumor necrosis factor receptor superfamily binding
GO:0033209 ISS tumor necrosis factor-mediated signaling pathway
GO:0034112 IDA positive regulation of homotypic cell-cell adhesion
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0045672 IDA positive regulation of osteoclast differentiation
GO:0045780 IDA positive regulation of bone resorption
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0050870 IDA positive regulation of T cell activation
GO:0051091 ISS positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051466 ISS positive regulation of corticotropin-releasing hormone secretion
GO:0071812 ISS positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847 IDA TNFSF11-mediated signaling pathway
GO:0071848 IDA positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
GO:1902533 IDA positive regulation of intracellular signal transduction

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000022592 Tnfsf11-201 protein_coding Mus_musculus 0 732

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