C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: apoptotic peptidase activating factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000120868 APAF1 9606 + 12:98645141-98735433 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000333991 APAF1-201 98645300-98735426 protein_coding
  ENST00000357310 APAF1-202 98645300-98735426 protein_coding
  ENST00000359972 APAF1-001 98645300-98735433 protein_coding
  ENST00000546491 APAF1-009 98699496-98712761 processed_transcript
  ENST00000547045 APAF1-005 98648355-98732687 protein_coding
  ENST00000547666 APAF1-008 98733648-98735418 processed_transcript
  ENST00000547743 APAF1-007 98645671-98648932 protein_coding
  ENST00000549007 APAF1-006 98648360-98732566 protein_coding
  ENST00000550527 APAF1-004 98648353-98735426 protein_coding
  ENST00000551964 APAF1-002 98645141-98733527 protein_coding
  ENST00000552268 APAF1-003 98648316-98732563 protein_coding
  ENST00000552929 APAF1-010 98723269-98733059 processed_transcript
  ENST00000555047 APAF1-011 98670861-98671697 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000357310ENST00000359972ENST00000546491ENST00000547045ENST00000547666ENST00000547743ENST00000549007ENST00000550527ENST00000551964ENST00000552268
Transcript ID Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000357310 N/A N/A N/A N/A N/A N/A N/A N/A 0.438±0.00 N/A N/A
ENST00000359972 N/A N/A N/A 0.217±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000546491 N/A N/A N/A N/A N/A N/A N/A N/A 4.114±0.00 N/A N/A
ENST00000547045 1.638±0.00 3.525±0.00 N/A N/A N/A N/A 2.937±0.00 0.355±0.00 2.645±0.00 N/A N/A
ENST00000547666 N/A N/A N/A N/A N/A N/A N/A N/A 2.928±1.23 1.761±1.09 5.528±0.00
ENST00000547743 N/A N/A N/A N/A N/A N/A 5.898±0.00 N/A N/A N/A N/A
ENST00000549007 N/A N/A N/A 0.274±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000550527 N/A N/A N/A 0.180±0.00 1.023±0.00 0.354±0.00 N/A N/A 0.694±0.03 N/A N/A
ENST00000551964 N/A 1.025±0.49 1.176±0.00 0.201±0.00 0.849±0.10 0.121±0.00 1.076±0.00 N/A 1.037±0.00 N/A 1.307±0.14
ENST00000552268 N/A N/A N/A N/A 2.063±0.00 N/A N/A N/A 4.052±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00090D CIL_00090D_0001 VISTA 12:98189717-98793261
CIL_0000T8 CIL_0000T8_0002 CGP 12:98645141-99984654

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 TAS nucleotide binding
GO:0001843 IEA neural tube closure
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005829 TAS cytosol
GO:0006915 TAS apoptotic process
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007275 IEA multicellular organismal development
GO:0007399 TAS nervous system development
GO:0007420 IEA brain development
GO:0008635 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008656 NAS cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0030900 IEA forebrain development
GO:0042802 IEA identical protein binding
GO:0042981 TAS:IEA regulation of apoptotic process
GO:0043065 TAS positive regulation of apoptotic process
GO:0043293 TAS apoptosome
GO:0043531 IEA ADP binding
GO:0051402 IEA neuron apoptotic process
GO:0070062 IDA extracellular vesicular exosome
GO:0072432 TAS response to G1 DNA damage checkpoint signaling
GO:0097190 IEA apoptotic signaling pathway
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:1902510 IEA regulation of apoptotic DNA fragmentation
GO:2001235 IEA positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021239 apaf1 apoptotic protease activating factor 1 protein_coding Danio_rerio
ENSMUSG00000019979 Apaf1 apoptotic peptidase activating factor 1 protein_coding Mus_musculus

Loading