C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: twist family bHLH transcription factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000122691 TWIST1 9606 - 7:19020991-19117672 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000242261 TWIST1-001 19115468-19117672 protein_coding
  ENST00000354571 TWIST1-003 19113047-19117118 nonsense_mediated_decay
  ENST00000443687 TWIST1-002 19020991-19116924 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000242261ENST00000354571ENST00000443687
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000242261 11.547±0.00 0.762±0.00 0.407±0.02 4.370±2.40 1.840±1.68 0.392±0.34 0.118±0.00 2.880±0.00 0.904±0.79 0.826±0.00 2.670±1.72 7.523±2.31 3.895±2.16
ENST00000354571 N/A 1.109±0.00 N/A 10.545±0.00 N/A N/A 0.194±0.00 N/A N/A N/A N/A N/A N/A
ENST00000443687 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.218±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008Z6 CIL_0008Z6_0001 VISTA 7:18529093-19130782
CIL_0008Z7 CIL_0008Z7_0001 VISTA 7:18534649-19135746
CIL_0008A9 CIL_0008A9_0001 VISTA 7:18546348-19147607
CIL_0007LO CIL_0007LO_0001 UCNEbase 7:18643621-19413840
CIL_0008VF CIL_0008VF_0001 VISTA 7:18807298-19410628
CIL_00084F CIL_00084F_0001 VISTA 7:18818071-19420090

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001503 TAS ossification
GO:0001649 IEA osteoblast differentiation
GO:0001701 IEA in utero embryonic development
GO:0001764 IEA neuron migration
GO:0001843 IEA neural tube closure
GO:0003180 IMP aortic valve morphogenesis
GO:0003183 IEA mitral valve morphogenesis
GO:0003203 IEA endocardial cushion morphogenesis
GO:0003253 IEA cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007517 IEA muscle organ development
GO:0008134 IPI transcription factor binding
GO:0010628 IMP positive regulation of gene expression
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0014067 IMP negative regulation of phosphatidylinositol 3-kinase signaling
GO:0019904 IEA protein domain specific binding
GO:0030154 IEA cell differentiation
GO:0030326 IEA embryonic limb morphogenesis
GO:0030500 IMP regulation of bone mineralization
GO:0032000 IMP positive regulation of fatty acid beta-oxidation
GO:0032720 IEA negative regulation of tumor necrosis factor production
GO:0032760 IMP positive regulation of tumor necrosis factor production
GO:0033128 IMP negative regulation of histone phosphorylation
GO:0035067 IEA negative regulation of histone acetylation
GO:0035115 IEA embryonic forelimb morphogenesis
GO:0035116 IEA embryonic hindlimb morphogenesis
GO:0035137 IEA hindlimb morphogenesis
GO:0035359 IEA negative regulation of peroxisome proliferator activated receptor signaling pathway
GO:0042473 TAS outer ear morphogenesis
GO:0042476 IEA odontogenesis
GO:0042733 TAS embryonic digit morphogenesis
GO:0042803 IEA protein homodimerization activity
GO:0043066 IEA negative regulation of apoptotic process
GO:0043425 IPI bHLH transcription factor binding
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043518 IMP negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044092 IEA negative regulation of molecular function
GO:0045596 IEA negative regulation of cell differentiation
GO:0045668 IMP negative regulation of osteoblast differentiation
GO:0045766 NAS positive regulation of angiogenesis
GO:0045843 IEA negative regulation of striated muscle tissue development
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IEA protein heterodimerization activity
GO:0046983 IEA protein dimerization activity
GO:0048511 IEA rhythmic process
GO:0048642 IEA negative regulation of skeletal muscle tissue development
GO:0048701 IMP embryonic cranial skeleton morphogenesis
GO:0048704 IEA embryonic skeletal system morphogenesis
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0060021 IEA palate development
GO:0060348 IEA bone development
GO:0060363 TAS cranial suture morphogenesis
GO:0060900 IMP embryonic camera-type eye formation
GO:0061029 IMP eyelid development in camera-type eye
GO:0061309 IEA cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0070888 IDA E-box binding
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071456 IMP cellular response to hypoxia
GO:0071639 IMP positive regulation of monocyte chemotactic protein-1 production
GO:2000147 NAS positive regulation of cell motility
GO:2000276 IEA negative regulation of oxidative phosphorylation uncoupler activity
GO:2000679 IMP positive regulation of transcription regulatory region DNA binding
GO:2000773 IMP negative regulation of cellular senescence
GO:2000778 IMP positive regulation of interleukin-6 secretion
GO:2000780 IMP negative regulation of double-strand break repair
GO:2000793 IMP cell proliferation involved in heart valve development
GO:2000802 IEA positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031277 twist1b twist1b protein_coding Danio_rerio
ENSDARG00000076010 twist1b twist1b protein_coding Danio_rerio
ENSMUSG00000035799 Twist1 twist basic helix-loop-helix transcription factor 1 protein_coding Mus_musculus

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