C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000125818 PSMF1 9606 + 20:1113263-1189415 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000246015 PSMF1-003 1118598-1167328 protein_coding
  ENST00000333082 PSMF1-201 1113263-1167782 protein_coding
  ENST00000335877 PSMF1-006 1118598-1168378 protein_coding
  ENST00000381898 PSMF1-010 1135278-1189415 protein_coding
  ENST00000381899 PSMF1-008 1113278-1135306 protein_coding
  ENST00000418246 PSMF1-009 1166280-1179952 processed_transcript
  ENST00000435720 PSMF1-004 1135178-1165059 protein_coding
  ENST00000478004 PSMF1-002 1118610-1135306 processed_transcript
  ENST00000479715 PSMF1-001 1113306-1164397 processed_transcript
  ENST00000484891 PSMF1-005 1134840-1168378 processed_transcript

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000246015ENST00000333082ENST00000335877ENST00000381899ENST00000435720ENST00000478004ENST00000479715ENST00000484891
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000246015 8.120±0.00 11.117±0.00 2.666±0.00 4.961±0.82 4.261±2.15 4.495±0.68 3.041±1.73 8.453±4.14 4.203±0.00 3.993±0.00 3.974±0.00 15.095±6.58 10.073±1.10 20.813±8.07
ENST00000333082 7.614±0.00 9.167±0.00 2.470±0.00 3.376±1.17 5.444±1.54 6.785±0.00 4.119±3.22 5.489±3.15 5.879±4.23 7.029±3.85 8.107±7.26 7.890±4.26 7.709±4.21 9.109±4.65
ENST00000335877 4.121±0.00 N/A N/A 1.945±0.23 1.594±0.00 2.321±0.00 N/A 2.440±0.90 2.391±0.48 1.850±0.86 2.118±1.36 3.329±0.24 2.847±0.00 N/A
ENST00000381899 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 44.543±13.36 20.537±0.00 33.606±0.00
ENST00000435720 74.619±0.00 N/A N/A 60.987±0.00 83.414±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 150.492±0.00
ENST00000478004 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 38.958±0.00 N/A
ENST00000479715 34.981±0.00 30.305±0.00 N/A 31.366±0.00 36.491±0.00 28.514±0.00 19.856±0.00 N/A 26.485±0.00 33.931±0.00 46.089±0.00 35.821±0.00 41.015±0.00 52.411±21.28
ENST00000484891 N/A N/A N/A N/A N/A 0.952±0.00 N/A N/A N/A N/A N/A 1.089±0.00 N/A 5.231±0.85

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004866 NAS endopeptidase inhibitor activity
GO:0005515 IPI protein binding
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005829 IDA cytosol
GO:0005839 NAS proteasome core complex
GO:0006511 IDA ubiquitin-dependent protein catabolic process
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467 TAS gene expression
GO:0010951 NAS negative regulation of endopeptidase activity
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070628 IDA proteasome binding
GO:1901799 IDA negative regulation of proteasomal protein catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022652 psmf1 proteasome (prosome, macropain) inhibitor subunit 1 protein_coding Danio_rerio
ENSMUSG00000032869 Psmf1 proteasome (prosome, macropain) inhibitor subunit 1 protein_coding Mus_musculus

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