C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: chemokine (C-C motif) receptor 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000126353 CCR7 9606 - 17:40553769-40565472 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000246657 CCR7-001 40553769-40565472 protein_coding
  ENST00000578085 CCR7-003 40555092-40565459 protein_coding
  ENST00000579344 CCR7-002 40554330-40561013 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000246657ENST00000578085ENST00000579344
Transcript ID Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000246657 0.068±0.00 N/A N/A 0.027±0.00 N/A 1.372±0.00 0.008±0.00 N/A 0.581±0.18 0.116±0.00
ENST00000578085 N/A 0.693±0.00 0.621±0.00 N/A 0.632±0.00 N/A N/A 0.341±0.00 N/A N/A
ENST00000579344 N/A N/A 0.102±0.00 0.127±0.00 0.124±0.00 0.303±0.00 N/A 0.213±0.00 0.117±0.00 0.335±0.04

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005QX CIL_0005QX_0001 CGP 17:40475828-40565472
CIL_0005QY CIL_0005QY_0001 CGP 17:40553769-40648508

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001768 IC establishment of T cell polarity
GO:0001954 IC positive regulation of cell-matrix adhesion
GO:0002407 IC dendritic cell chemotaxis
GO:0002408 IDA myeloid dendritic cell chemotaxis
GO:0002606 ISS positive regulation of dendritic cell antigen processing and presentation
GO:0002885 ISS positive regulation of hypersensitivity
GO:0002922 ISS positive regulation of humoral immune response
GO:0004930 TAS:IEA G-protein coupled receptor activity
GO:0005515 IEA protein binding
GO:0005622 IDA intracellular
GO:0005886 IDA plasma membrane
GO:0006935 IEA chemotaxis
GO:0006954 IEA:NAS inflammatory response
GO:0006955 IEA immune response
GO:0007186 IEA:TAS G-protein coupled receptor signaling pathway
GO:0007204 TAS positive regulation of cytosolic calcium ion concentration
GO:0009897 IEA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0016021 IEA integral component of membrane
GO:0016493 ISS C-C chemokine receptor activity
GO:0030838 IC positive regulation of actin filament polymerization
GO:0031274 IC positive regulation of pseudopodium assembly
GO:0031529 IC ruffle organization
GO:0032496 IEA response to lipopolysaccharide
GO:0032649 ISS regulation of interferon-gamma production
GO:0032735 ISS positive regulation of interleukin-12 production
GO:0032862 IC activation of Rho GTPase activity
GO:0034695 IC response to prostaglandin E
GO:0035757 IPI chemokine (C-C motif) ligand 19 binding
GO:0035758 IPI chemokine (C-C motif) ligand 21 binding
GO:0038115 IDA chemokine (C-C motif) ligand 19 signaling pathway
GO:0038116 IDA chemokine (C-C motif) ligand 21 signaling pathway
GO:0038117 IDA C-C motif chemokine 19 receptor activity
GO:0038121 IDA C-C motif chemokine 21 receptor activity
GO:0043123 IC positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043552 IC positive regulation of phosphatidylinositol 3-kinase activity
GO:0045060 IEA negative thymic T cell selection
GO:0045785 IC positive regulation of cell adhesion
GO:0045860 IC positive regulation of protein kinase activity
GO:0046330 IC positive regulation of JNK cascade
GO:0050706 ISS regulation of interleukin-1 beta secretion
GO:0050862 IEA positive regulation of T cell receptor signaling pathway
GO:0051209 IC release of sequestered calcium ion into cytosol
GO:0051491 IC positive regulation of filopodium assembly
GO:0051897 IC positive regulation of protein kinase B signaling
GO:0070098 IEA:ISS chemokine-mediated signaling pathway
GO:0070374 IC positive regulation of ERK1 and ERK2 cascade
GO:0071345 IDA cellular response to cytokine stimulus
GO:0071731 IC response to nitric oxide
GO:0072610 ISS interleukin-12 secretion
GO:0090023 IDA positive regulation of neutrophil chemotaxis
GO:0097022 TAS lymphocyte migration into lymph node
GO:0097029 ISS mature dendritic cell differentiation
GO:2000107 IC negative regulation of leukocyte apoptotic process
GO:2000147 IC positive regulation of cell motility
GO:2000510 ISS positive regulation of dendritic cell chemotaxis
GO:2000522 ISS positive regulation of immunological synapse formation
GO:2000525 ISS positive regulation of T cell costimulation
GO:2000526 ISS positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
GO:2000547 ISS regulation of dendritic cell dendrite assembly

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044561 ccr7 chemokine (C-C motif) receptor 7 protein_coding Danio_rerio
ENSMUSG00000037944 Ccr7 chemokine (C-C motif) receptor 7 protein_coding Mus_musculus

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